The limitations of cisplatin as an anticancer drug have stimulated the search for other
antitumor-active platinum complexes with improved pharmacological properties. The two …

The vast amount of basic research on platinum coordination complexes has produced, over
the past 25 years, several thousand new molecules for preclinical screening and 28 …

Cisplatin, carboplatin and oxaliplatin continue to be among the most efficient anticancer
drugs in world-wide clinical use so far. In particular, cisplatin has shown a remarkable …

Research in the field of bioinorganic chemistry has been stimulated by the worldwide
success of the anticancer drug cisplatin. 40 years after the first report about its biological …

Over the past two decades, platinum-based drugs (cis-platin and, latterly, the less toxic
analogue carboplatin) have conferred significant therapeutic benefit to a large number of …

Cisplatin is an essential antineoplastic agent whose introduction in clinical use
revolutionized the treatment of several solid malignancies, especially those of germinative …

Background: The platinum (II) complexes as anticancer agents have been well explored for
the development of novel analogs. Yet, none of them achieved clinical importance in …

Platinum drugs are widely used in antitumour therapy and are a cornerstone of the treatment
of different solid tumours. The pharmacological interest of cisplatin has led to the design of …

The impact of cisplatin on cancer chemotherapy cannot be denied. Over the past 20 years,
much effort has been dedicated to discover new platinum‐based anticancer agents that are …

Platinum-based anticancer chemotherapy constitutes a cornerstone for the treatment of
various solid tumors. However, existing platinum drugs like cisplatin encounter many …