The role of Rat1 in coupling mRNA 3′-end processing to transcription termination: implications for a unified allosteric–torpedo model
The torpedo model of transcription termination by RNA polymerase II proposes that a 5′–
3′ RNA exonuclease enters at the poly (A) cleavage site, degrades the nascent RNA, and …
3′ RNA exonuclease enters at the poly (A) cleavage site, degrades the nascent RNA, and …
The multifunctional protein p54nrb/PSF recruits the exonuclease XRN2 to facilitate pre-mRNA 3′ processing and transcription termination
S Kaneko, O Rozenblatt-Rosen… - Genes & …, 2007 - genesdev.cshlp.org
Termination of RNA polymerase II transcription frequently requires a poly (A) signal and
cleavage/polyadenylation factors. Recent work has shown that degradation of the …
cleavage/polyadenylation factors. Recent work has shown that degradation of the …
DNA-directed termination of mammalian RNA polymerase II
The best-studied mechanism of eukaryotic RNA polymerase II (RNAPII) transcriptional
termination involves polyadenylation site-directed cleavage of the nascent RNA. The RNAPII …
termination involves polyadenylation site-directed cleavage of the nascent RNA. The RNAPII …
[HTML][HTML] Mechanism of transcription termination by RNA polymerase III utilizes a non-template strand sequence-specific signal element
AG Arimbasseri, RJ Maraia - Molecular cell, 2015 - cell.com
Understanding the mechanism of transcription termination by a eukaryotic RNA polymerase
(RNAP) has been limited by lack of a characterizable intermediate that reflects transition …
(RNAP) has been limited by lack of a characterizable intermediate that reflects transition …
[HTML][HTML] Poly (A) signal-dependent transcription termination occurs through a conformational change mechanism that does not require cleavage at the poly (A) site
Transcription termination for genes encoding polyadenylated mRNAs requires a functional
poly (A) signal (PAS) in the nascent pre-mRNA. Often called PAS-dependent termination, or …
poly (A) signal (PAS) in the nascent pre-mRNA. Often called PAS-dependent termination, or …
A unified allosteric/torpedo mechanism for transcriptional termination on human protein-coding genes
JD Eaton, L Francis, L Davidson… - Genes & …, 2020 - genesdev.cshlp.org
The allosteric and torpedo models have been used for 30 yr to explain how transcription
terminates on protein-coding genes. The former invokes termination via conformational …
terminates on protein-coding genes. The former invokes termination via conformational …
Transcription termination by nuclear RNA polymerases
P Richard, JL Manley - Genes & development, 2009 - genesdev.cshlp.org
Gene transcription in the cell nucleus is a complex and highly regulated process.
Transcription in eukaryotes requires three distinct RNA polymerases, each of which employs …
Transcription in eukaryotes requires three distinct RNA polymerases, each of which employs …
[HTML][HTML] Yeast RNase III triggers polyadenylation-independent transcription termination
Transcription termination of messenger RNA (mRNA) is normally achieved by
polyadenylation followed by Rat1p-dependent 5′-3′ exoribonuleolytic degradation of the …
polyadenylation followed by Rat1p-dependent 5′-3′ exoribonuleolytic degradation of the …
[HTML][HTML] The yeast 5′-3′ exonuclease Rat1p functions during transcription elongation by RNA polymerase II
S Jimeno-González, LL Haaning, F Malagon… - Molecular cell, 2010 - cell.com
Termination of RNA polymerase II (RNAPII) transcription of protein-coding genes occurs
downstream of cleavage/polyadenylation sites. According to the" torpedo" model, the 5 …
downstream of cleavage/polyadenylation sites. According to the" torpedo" model, the 5 …
Efficient termination of transcription by RNA polymerase I requires the 5′ exonuclease Rat1 in yeast
During transcription termination by RNA polymerase II on protein-coding genes, the nuclear
5′ exonuclease Rat1/Xrn2 degrades the nascent transcript downstream from the …
5′ exonuclease Rat1/Xrn2 degrades the nascent transcript downstream from the …