Chronic asthma is an inflammatory airways disease characterized by pathological changes
in the airway smooth muscle (ASM) bundle that contribute to airway obstruction and …

Recent evidence points to progressive structural change in the airway wall, driven by
chronic local inflammation, as a fundamental component for development of irreversible …

The airway smooth muscle cell can contract; relax; participate in allergic and inflammatory
responses by expressing adhesion molecules, releasing cytokines, and producing matrix …

It is now established that airway smooth muscle (ASM) has roles in determining airway
structure and function, well beyond that as the major contractile element. Indeed, changes in …

The airway smooth muscle (ASM) cell plays a central role in the pathogenesis of asthma and
constitutes an important target for treatment. These cells control muscle tone and thus …

Introduction Asthma is characterized by enhanced airway contractility and remodeling where
airway smooth muscle (ASM) plays a key role, modulated by inflammation. Understanding …

Airway smooth muscle (ASM) plays a pivotal role in modulating bronchomotor tone but also
orchestrates and perpetuates airway inflammation and remodeling. Despite substantial …

Airway inflammation, airflow obstruction, and bronchial hyperresponsiveness are
characteristic phenotypic features of asthma. Clinically, airflow obstruction in asthma often is …

Rationale: Ventilatory defects in asthma are heterogeneous and may represent the
distribution of airway smooth muscle (ASM) remodeling. Objectives: To determine the …

Asthma is an obstructive airway disease, with a heterogeneous and multifactorial
pathogenesis. Although generally considered to be a disease principally driven by chronic …