Abstract The intrinsically disordered, 18.5-kDa isoform of myelin basic protein (MBP) is a
peripheral membrane protein that is essential to proper myelin formation in the central …

Intrinsically-disordered proteins (IDPs) present a complex interplay of conformational
variability and multifunctionality, modulated by environment and post-translational …

Numerous human proteins are classified as intrinsically disordered proteins (IDPs). Due to
their physicochemical properties, high-resolution structural information about IDPs is …

The classic isoforms of myelin basic protein (MBP) are essential for the formation and
maintenance of myelin in the central nervous system of higher vertebrates. The protein is …

The osmolyte trimethylamine-N-oxide (TMAO) is a naturally in vivo occurring “chemical
chaperone” that has been shown to stabilise the folding of numerous proteins. Myelin basic …

The 18.5 kDa isoform of myelin basic protein is essential to maintaining the close apposition
of myelin membranes in central nervous system myelin, but its intrinsic disorder …

Using solution NMR spectroscopy, three‐dimensional structures have been obtained for an
18‐residue synthetic polypeptide fragment of 18.5 kDa myelin basic protein (MBP, human …

Central nervous system myelin is a dynamic entity arising from membrane processes
extended from oligodendrocytes, which form a tightly-wrapped multilamellar structure …

The 18.5 kDa isoform of myelin basic protein (MBP) is a peripheral membrane protein that
maintains the structural integrity of the myelin sheath of the central nervous system by …

The 18.5 kDa isoform of myelin basic protein (MBP) is the predominant form in adult human
central nervous system myelin. It is an intrinsically disordered protein that functions both in …