The possibility of using the RNA interference (RNAi) mechanisms in gene therapy was one
of the scientific breakthroughs of the last century. Despite the extraordinary therapeutic …

Gene silencing agents, like small interfering RNA (siRNA), are powerful tools widely used in
therapeutic and fundamental studies. However, major limitations to their in vivo and in vitro …

The 'RNA interference'has emerged as a potential therapeutic strategy owing to its high
specificity to silent any malfunctioned gene in diseases with genetic background. Currently …

RNA interference (RNAi) is an evolutionary conserved highly specific gene-silencing
mechanism initiated by small interfering RNA (siRNA) molecules. Fast-paced preclinical and …

In recent year, cationic liposomes have gained a lot of attention for siRNA delivery. Despite
this, intracellular barriers as endosomal escape and cytosolic delivery of siRNA still …

Nucleic Acid Based Drugs (NABDs) constitute a class of promising and powerful therapeutic
new agents with limited side effects, potentially useable against a wide range of diseases …

The potency of biomolecules assures therapy for as well as prevention of many disorders.
However, their stability and delivery to the site of action remain a major challenge for …

Over the past two decades, small interfering RNA (siRNA) has gained widespread popularity
as an efficient tool for cancer therapy. Unfortunately, due to its inherent instability, the …

In the last years the rapid development of Nucleic Acid Based Drugs (NABDs) to be used in
gene therapy has had a great impact in the medical field, holding enormous promise …

Small interfering RNAs (siRNA) have recently emerged as a new class of therapeutics with a
great potential to revolutionize the treatment of cancer and other diseases. A specifically …