Modulation of hypoxia is an essential factor for enhancing the effects of antitumor therapies,
especially sonodynamic therapy and chemotherapy. To improve the efficacy of combination …

Pancreatic cancer is a severe disease that threatens human health. The hypoxic tumor
microenvironment in pancreatic cancer leads to resistance to conventional therapies and …

Sonodynamic therapy (SDT) has been explored for cancer therapy, especially for deep
tumors due to its low tissue penetration restriction. The therapeutic efficacy of SDT is limited …

Hypoxia, the typical and conspicuous characteristic of most solid tumors, worsens the tumor
invasiveness and metastasis. Here, we engineered a sequential ultrasound (US)/hypoxia …

An ultrasound-triggered sonodynamic therapy has shown great promise for cancer therapy.
However, its clinical applications are very limited because the traditional sonosensitizers …

Sonodynamic therapy (SDT), which uses reactive oxygen species to target tumors, has
shown promise in the management of unresectable cancers. However, the hypoxic tumor …

Tumor hypoxia restricts anti-tumor efficacy of aerobic therapies such as chemotherapy and
sonodynamic therapy (SDT), and efforts in this area are focused on developing …

Sonodynamic therapy (SDT), as a new method of non-invasive tumor treatment developed
from photodynamic therapy (PDT), can overcome the disadvantage of poor laser penetration …

Background Hypoxia-activated prodrug (HAP) is a promising candidate for highly tumor-
specific chemotherapy. However, the oxygenation heterogeneity and dense extracellular …

Hypoxia as one characteristic hallmark of solid tumors has been demonstrated to be
involved in cancer metastasis and progression, induce severe resistance to oxygen …