Local delivery to malignant brain tumors: Potential biomaterial-based therapeutic/adjuvant strategies

M Alghamdi, M Gumbleton, B Newland - Biomaterials Science, 2021 - pubs.rsc.org
Glioblastoma (GBM) is the most aggressive malignant brain tumor and is associated with a
very poor prognosis. The standard treatment for newly diagnosed patients involves total …

Rationally designed drug delivery systems for the local treatment of resected glioblastoma

C Bastiancich, A Malfanti, V Préat, R Rahman - Advanced drug delivery …, 2021 - Elsevier
Glioblastoma (GBM) is a particularly aggressive brain cancer associated with high
recurrence and poor prognosis. The standard of care, surgical resection followed by …

Local strategies and delivery systems for the treatment of malignant gliomas

F Yu, S Asghar, M Zhang, J Zhang, Q Ping… - Journal of Drug …, 2019 - Taylor & Francis
Glioma is one of the most common type of malignant tumours with high morbidity and
mortality rates. Due to the particular features of the brain, such as blood–brain barrier or …

Injectable local drug delivery systems for glioblastoma: a systematic review and meta-analysis of progress to date

Y Wang, C Bastiancich, B Newland - Biomaterials Science, 2023 - pubs.rsc.org
Glioblastoma (GBM) is an aggressive malignant cancer associated with bleak prognosis and
high mortality. The current standard of care for GBM is maximum surgical resection plus …

Delivery of local therapeutics to the brain: working toward advancing treatment for malignant gliomas

KL Chaichana, L Pinheiro, H Brem - Therapeutic delivery, 2015 - Taylor & Francis
Malignant gliomas, including glioblastoma and anaplastic astrocytomas, are characterized
by their propensity to invade surrounding brain parenchyma, making curative resection …

Role of polymeric local drug delivery in multimodal treatment of malignant glioma: a review

YY Tseng, TY Chen, SJ Liu - International Journal of …, 2021 - Taylor & Francis
Malignant gliomas (MGs) are the most common and devastating primary brain tumor. At
present, surgical interventions, radiotherapy, and chemotherapy are only marginally …

Anticancer drug-loaded hydrogels as drug delivery systems for the local treatment of glioblastoma

C Bastiancich, P Danhier, V Préat, F Danhier - Journal of Controlled …, 2016 - Elsevier
Among central nervous system tumors, Glioblastoma (GBM) is the most common, aggressive
and neurological destructive primary brain tumor in adults. Standard care therapy for GBM …

Novel advances in drug delivery to brain cancer

MS Lesniak - Technology in cancer research & treatment, 2005 - journals.sagepub.com
The therapy of brain tumors has been limited by a lack of effective methods of drug delivery
to the brain. Systemic administration is often associated with toxic side effects and ultimately …

Local delivery and glioblastoma: why not combining sustained release and targeting?

C Gazaille, M Sicot, P Saulnier, J Eyer… - Frontiers in Medical …, 2021 - frontiersin.org
Glioblastoma is one of the most aggressive brain tumors and is associated with a very low
overall median survival despite the current treatment. The standard of care used in clinic is …

[HTML][HTML] Local drug delivery strategies for glioblastoma treatment

GD Cha, S Jung, SH Choi… - Brain Tumor Research …, 2022 - synapse.koreamed.org
Glioblastoma multiforme (GBM) is a brain tumor notorious for its malignancy. The key reason
for the limited efficacy of standard treatment is the high recurrence rate of GBM, even after …