Anticancer profile and anti-inflammatory effect of new N-(2-((4-(1, 3-diphenyl-1H-pyrazol-4-yl) pyridine sulfonamide derivatives

MS Abdel-Maksoud, RM Hassan, AAS El-Azzouny… - Bioorganic …, 2021 - Elsevier
A new series of N-(2-((4-(1, 3-diphenyl-1H-pyrazol-4-yl) pyridine sulfonamide derivatives
11a-o were designed and synthesized based on our previous works. The new series was …

Novel thiourea derivatives bearing sulfonamide moiety as anticancer agents through COX-2 inhibition

MM Ghorab, M SA El-Gaby, MS Alsaid… - Anti-Cancer Agents …, 2017 - ingentaconnect.com
Background: Thiourea derivatives bearing sulfonamide moiety are well known for their
anticancer activity. Objective: The anticancer activity of the target compounds was studied …

[PDF][PDF] Synthesis and preliminary evaluation of potential highly selective COX-2 inhibitors of some nonsteroidal anti-inflammatory derivatives

M Alherwi, S Almekhlafi, AH Ahmed… - Journal of Chemical …, 2016 - researchgate.net
This work include design and synthesis of novel nonsteroidal anti-inflammatory (NSAI)
derivatives, with potential selectivity cyclooxygenase 2 (COX-2) inhibitors from well-known …

Design, synthesis and biological evaluation of pyridine acyl sulfonamide derivatives as novel COX-2 inhibitors

X Lu, H Zhang, X Li, G Chen, QS Li, Y Luo… - Bioorganic & medicinal …, 2011 - Elsevier
A series of pyridine acyl sulfonamide derivatives (1–24) have been designed and
synthesized and their biological activities were also evaluated as potential cyclooxygenase …

[PDF][PDF] Synthesis and Characterization of New Ligands attached to NSAIDs Moiety

MF Mahdi, AH Dawood, AM Hantoush - Int J Adv Res, 2015 - researchgate.net
Non-Steroidal Anti Inflammatory Drugs (NSAIDs) have been commonly used in both humans
and animals as remedies to relieve pain and inflammation in different arthritic and …

Synthesis, anti-inflammatory activity, and in vitro antitumor effect of a novel class of cyclooxygenase inhibitors: 4-(Aryloyl) phenyl methyl sulfones

Y Harrak, G Casula, J Basset, G Rosell… - Journal of medicinal …, 2010 - ACS Publications
Following our previous research on anti-inflammatory drugs (NSAIDs), we report on the
design and synthesis of 4-(aryloyl) phenyl methyl sulfones. These substances were …

Perspectives of the application of non-steroidal anti-inflammatory drugs in cancer therapy: Attempts to overcome their unfavorable side effects

V Thiruchenthooran, E Sánchez-López, A Gliszczyńska - Cancers, 2023 - mdpi.com
Simple Summary The application of non-steroidal anti-inflammatory drugs (NSAIDs) in
cancer therapy has been a widely studied topic for almost four decades. This review …

New nonsteroidal anti‐inflammatory molecules with reduced photodegradation side effects and enhanced COX‐2 selectivity

KAK Musa, VR Palwai… - International Journal of …, 2011 - Wiley Online Library
Nonsteroidal anti‐inflammatory drugs (NSAIDs) are widely used as antipyretic, analgesic,
and anti‐inflammatory agents. However, they are also associated with a range of side …

Anti-cancer acitivity of etodolac and its derivatives on prostate and colorectal cancer cell lines

SK Sevinç, O Orun, PM Tiber, P Çıkla-Süzgün… - Proceedings, 2018 - mdpi.com
Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used as anti-inflammatory
and analgesic agents. This family of drugs suppresses prostaglandin synthesis through …

Evaluation of preventive and therapeutic activity of novel non-steroidal anti-inflammatory drug, CG100649, in colon cancer: Increased expression of TNF-related …

JK Woo, JH Kang, YS Jang, S Ro… - Oncology …, 2015 - spandidos-publications.com
Non-steroidal anti-inflammatory drugs (NSAIDs) have been suggested as the potential new
class of preventive or therapeutic antitumor agents. The aim of the present study was to …