Introduction: Targeting of inflammatory states with non-steroidal anti-inflammatory drugs
(NSAID'S) is an attractive proposition for cancer prevention. There is abundant …

This study includes design and synthesis of new non-steroidal anti-inflammatory agents
(NSAIDs) with expected cyclooxygenase-2 (COX-2) selective inhibition to achieve better …

Abstract A series of (E)-N-benzyl-1-(2, 4-dimethoxy-6-(4 methoxystyryl) phenyl)
methanamine (DMPM) derivatives (D1-D25) were successfully synthesized in the form of …

Novel quinoxaline derivatives (2a–d, 3, 4a, 4b and 5–15) have been synthesized via the
reaction of 4-methyl-3-oxo-3, 4-dihydroquinoxaline-2-carbohydrazide (1) with different …

Background: Non-steroidal anti-inflammatory drugs (NSAIDs) may be able to enhance the
antitumor effect of cancer drugs. Cyclooxygenase-2 (COX-2) is the best characterized target …

Two series of NSAIDs-EBS derivatives (5a-j and 9a-i) based on the hybridization of
nonsteroidal anti-inflammatory drugs (NSAIDs) skeleton and Ebselen moiety were …

Certain non-steroidal anti-inflammatory drugs (NSAIDs) are known to have anticancer
effects. However, it is unclear whether all NSAIDs have anticancer effects, and thus far, very …

A new series of NSAID thioesters were synthesized and evaluated for their in vitro antitumor
effects against a panel of four human tumor cell lines, namely: HepG2, MCF-7, HCT-116 and …

A new series of linker-based derivatives of non-steroidal anti-inflammatory drugs were
designed and synthesized. All the compounds were well characterized with the help of …

Background: Dual-targeting/Multi-targeting of oncoproteins by a single drug molecule
represents an efficient, logical and alternative approach to drug combinations. In silico …