Novel differently substituted pyrazole derivatives were designed, synthesized and evaluated
for their anticancer activity. All compounds selectively inhibited COX-2 enzyme (IC 50 …

Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely used
medications as analgesics and antipyretics. Currently, there is a growing interest in their …

Cyclooxygenase inhibitors as anti-inflammatory agents can be used in chemoprevention.
Many in vitro and in vivo studies on human and animal models have explained the …

The present study was designed to investigate the combined effects of cyclooxygenase
(COX)-1 and COX-2 selective inhibitors on human ovarian SKOV-3 carcinoma cells …

Background: Several clinically used COX-1 and COX-2 inhibitor drugs were reported to
possess severe side effects like GI ulcers and cardiovascular disturbances, respectively …

Abstract New imidazol-5-one derivatives 12a, b and 12e, f, 14a, b and 16a, b were
synthesized and screened for their in vivo anti-inflammatory activity using a standard acute …

Nonsteroidal anti-inflammatory drugs inhibit cell proliferation and induce apoptosis in
various cancer cell lines, which is considered to be an important mechanism for their anti …

Cyclooxygenase-2 (COX-2) inhibitor nimesulide inhibits the proliferation of various types of
cancer cells mainly via COX-2 independent mechanisms, which makes it a good lead …

Herein, a novel series of 1, 3-diaryl pyrazolyl ester derivatives were synthesized and
evaluated as potential COX-2 inhibitory candidates with anti-tumor effect. Among the four …

Objective of the present work was to evaluate the anti-inflammatory, ulcerogenicity and
cyclooxygenase activity of indenopyrimidine derivatives. Anti-inflammatory activity of the …