For more than a century, inhibition of prostaglandin biosynthesis via inhibition of the fatty
acid cyclooxygenase (COX) has been achieved by non-steroidal anti-inflammatory drugs …

Cyclooxygenase-2 (COX-2) as a rate-limiting metabolism enzyme of arachidonic acid has
been found to be implicated in tumor occurrence, angiogenesis, metastasis as well as …

Two new series of pyrazole derivatives 10a-f and 11a-f with selective COX-2 inhibition
pharmacophore and oxime/nitrate moieties as NO donor moiety were designed, synthesized …

In this study, we investigated the inhibition effects of matairesinol, pregnanolone,
hamamelitannin, secoisolariciresinol, and secoisolariciresinol diglicoside compounds on …

Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit proliferation and induce apoptosis in
human colorectal cancer cells in vitro. It remains unclear whether individual NSAIDs act by …

Two series of cyanopyrimidine hybrids were synthesized bearing either benzo [d] imidazole,
benzo [d] oxazole, benzo [d] thiazole, and benzo [b] thiophene derivatives via methylene …

Background Nonsteroidal anti-inflammatory drugs (NSAIDs) have been shown to have
antitumor effects in various systems including in vitro cell cultures of human cancer cell lines …

Background Increasingly, the role of chronic inflammation and its mediators in tumor
generation and progression is gaining importance in the field of cancer research. In this …

Background: Cervical cancer is one of the most common cancers worldwide. A promising,
novel strategy for cancer treatment is chemoprevention. Non-steroidal anti-inflammatory …

Objective: The pathology of every disease passes through the inflammation stage; hence,
the design and optimization of potential lead compounds as anti-inflammatory agents is still …