To elucidate potential mechanisms for insulin resistance occurring early in the development
of type 2 diabetes, we studied 10 young healthy individuals, each with two first-degree …

Type 2 diabetes is characterized by resistance to insulin action of glucose metabolism and
lipolysis. First‐degree relatives of diabetic patients are at increased risk of developing …

The mechanisms underlying insulin resistance in Type 2 (non-insulin-dependent) diabetes
mellitus are not fully understood. An enhanced lipid/non-esterified fatty acid oxidation could …

This study was undertaken to examine whether insulin resistance in adolescents with poorly
controlled type 1 diabetes mellitus (T1DM) is associated with the failure of insulin to …

Objective: The goal of this study was to quantify differences in lipid metabolism and insulin
sensitivity in black and white subjects to explain ethnic clinicopathological differences in …

Objective To test the hypothesis that multitissue deficits in insulin sensitivity are greater
among women than men with type 1 diabetes compared to respective controls. Research …

To evaluate the mechanism of insulin resistance in type 1 diabetes mellitus, we measured
insulin sensitivity in vivo and insulin action in adipocytes in vitro. The study groups consisted …

It is unclear from previous studies whether qualitative or only quantitative differences exist in
insulin action in adipocytes obtained from obese subjects with non-insulin-dependent …

The long-term complications associated with diabetes such as heart disease, kidney failure,
blindness, and limb amputations are mostly the result of chronic elevations in blood glucose …

In the transition from normal glucose tolerance (NGT) to type 2 diabetes mellitus (T2DM), the
role of β-cell dysfunction and peripheral insulin resistance (IR) is well established. However …