This review explains the effects of naproxen and the naproxen moiety in important biological
activities. Naproxen, 2-(6-methoxynaphthalen-2-yl) propionic acid, is one of the most utilized …

A structure-based medicinal chemistry strategy was applied to design new naproxen
derivatives that show growth inhibitory activity against human colon tumor cells through a …

A series of substituted 2-(6-methoxynapthalen-2-yl) propanoic acid (naproxen) analogs
were synthesized.(S)-naproxen (1) was treated with thionyl chloride to yield acid chloride (2) …

A new series of non-carboxylic naproxen analogues, bearing a variety of ring systems, such
as oxadiazoles 3a–c and 6a–c, cycloalkanes 4a–d, cyclic imides 5a–c, and triazoles 7–9 …

Background Increasingly, the role of chronic inflammation and its mediators in tumor
generation and progression is gaining importance in the field of cancer research. In this …

The isolation and characterisation of (S)-(+)-6-methoxy-α-methyl-2-naphthaleneacetic acid,
a well known synthetic non-steroidal anti-inflammatory drug (naproxene), from a natural …

Inflammation is a fundamental physiological process that is essential for survival of human
being but at the same time is one of the major causes of human morbidity and mortality. In …

Non-steroidal anti-inflammatory drugs (NSAIDs) achieve their anti-inflammatory actions
through an inhibitory effect on cyclooxygenase (COX). Two COX subtypes, COX-1 and COX …

Objective: The objective of this search was to synthesize a new naproxen analogues having
a 1, 2, 4-triazole-3-thiol heterocyclic ring, and preliminary pharmacological assessment of …

NSAIDs displayed chemopreventive and anticancer effects against several types of cancers.
Moreover, combination of NSAIDs with anticancer agents resulted in enhanced anticancer …