Lipid peroxidation (LPO) plays a key role in many age-related neurodegenerative conditions
and other disorders. Light irradiation can initiate LPO through various mechanisms and is of …

Autoxidation of polyunsaturated fatty acids (PUFAs) damages lipid membranes and
generates numerous toxic by‐products implicated in neurodegeneration, aging, and other …

Abstract Docosahexaenoic acid (DHA, 22: 6n-3), a long-chain polyunsaturated fatty acid
(PUFA) with important functions in normal human retinal activity and vision development, is …

Lipophilic photosensitizers able to photo-induce lipid oxidation in biomembranes are, in
general, much more efficient than hydrophilic ones; acting through the formation of singlet …

Oxidative cleavage of docosahexaenoate (DHA) in retinal pigmented epithelial (RPE) cells
produces 4-hydroxy-7-oxohept-5-enoic acid (HOHA) esters of 2-lysophosphatidylcholine …

Phototoxic degeneration of the retina was first described by Noell, Walker, Kang, and
Berman in 1966 and these authors also advanced the theory that polyunsaturated fatty acid …

Oxidative stress results from the attack by free radicals of several cellular targets (proteins,
DNA and lipids). The cell equilibrium is a direct consequence of the pro-/antioxidant …

Many pathologies of the central nervous system (CNS) originate from excess of reactive free
radicals, notably reactive oxygen species (ROS), and oxidative stress. A phenomenon which …

Photochemical and oxidative damages in retinal pigment epithelial (RPE) cells are key
events in the pathogenesis of age-related macular degeneration. Polyunsaturated fatty acids …

The mammalian retina contains a high level of polyunsaturated fatty acids, including
docosahexaenoic acid (22: 6)(DHA), which are highly susceptible to oxidation. It has been …