The importance of co‐delivery of nanoparticle‐siRNA and anticancer agents in cancer therapy

N Khelghati… - Chemical Biology & …, 2021 - Wiley Online Library
According to global statistics, cancer is the second leading cause of death worldwide.
Because of the heterogeneity of cancer, single‐drug therapy has many limitations due to low …

Nanoparticle‐mediated siRNA delivery and multifunctional modification strategies for effective cancer therapy

M Chen, C Dong, S Shi - Advanced Materials Technologies, 2021 - Wiley Online Library
RNA interference (RNAi), which can inhibit the expression or transcription of specific genes,
is considered to be a revolutionary tool for mediating gene therapy. Small interfering RNA …

Tumor‐targeting multifunctional nanoparticles for siRNA delivery: Recent advances in cancer therapy

SH Ku, K Kim, K Choi, SH Kim… - Advanced healthcare …, 2014 - Wiley Online Library
RNA interference (RNAi) is a naturally occurring regulatory process that controls
posttranscriptional gene expression. Small interfering RNA (siRNA), a common form of RNAi …

Nanoparticle-mediated co-delivery of chemotherapeutic agent and siRNA for combination cancer therapy

B Xiao, L Ma, D Merlin - Expert opinion on drug delivery, 2017 - Taylor & Francis
Introduction: Cancer is the leading cause of death worldwide. Current cancer treatments in
the clinic mainly include chemotherapy, radiotherapy and surgery, with chemotherapy being …

Nanoparticle-mediated delivery of siRNA for effective lung cancer therapy

YD Kim, TE Park, B Singh, S Maharjan, YJ Choi… - …, 2015 - Taylor & Francis
Lung cancer is one of the most lethal diseases worldwide, and the survival rate is less than
15% even after the treatment. Unfortunately, chemotherapeutic treatments for lung cancer …

Recent advancements in the design of nanodelivery systems of siRNA for cancer therapy

DN Yadav, MS Ali, AM Thanekar, SV Pogu… - Molecular …, 2022 - ACS Publications
RNA interference (RNAi) has increased the possibility of restoring RNA drug targets for
cancer treatment. Small interfering RNA (siRNA) is a promising therapeutic RNAi tool that …

Insights on prospects of nano-siRNA based approaches in treatment of Cancer

R Goyal, H Chopra, I Singh, K Dua… - Frontiers in …, 2022 - frontiersin.org
siRNA interference, commonly referred to as gene silence, is a biological mechanism that
inhibits gene expression in disorders such as cancer. It may enhance the precision, efficacy …

[HTML][HTML] Nano-formulated siRNA-based therapeutic approaches for cancer therapy

D Jain, SK Prajapati, A Jain, R Singhal - Nano Trends, 2023 - Elsevier
RNAi is a remarkable treatment strategy to knock down gene overexpression in a variety of
disorders, including cancers. RNAi processes allow siRNAs to detect and degrade a …

Nanoparticle-based combination therapy for cancer treatment

J Young Yhee, S Son, H Lee… - Current pharmaceutical …, 2015 - ingentaconnect.com
In recent years, combination of different types of therapies using nanoparticles has emerged
as an advanced strategy for cancer treatment. Most of all, combination of chemotherapeutic …

Nanoparticle‐mediated siRNA delivery systems for cancer therapy

H Gao, R Cheng, H A. Santos - View, 2021 - Wiley Online Library
The small interfering RNA (siRNA)‐based therapeutics have raised great attention since the
first RNA interference (RNAi)‐derived drug, patisiran, was approved by the US Food and …