[HTML][HTML] Vitamin K supplementation for prevention of vascular calcification in chronic kidney disease patients: are we there yet?

S Roumeliotis, A Duni, V Vaios, A Kitsos… - Nutrients, 2022 - mdpi.com
Chronic Kidney Disease (CKD) patients are at high risk of presenting with arterial
calcification or stiffness, which confers increased cardiovascular mortality and morbidity. In …

[HTML][HTML] Effects of vitamin K supplementation on vascular calcification in chronic kidney disease: a systematic review and meta-analysis of randomized controlled trials

C Geng, L Huang, L Pu, Y Feng - Frontiers in Nutrition, 2023 - frontiersin.org
Background There is conflicting data on the effect of vitamin K supplementation against
vascular calcification in chronic kidney disease (CKD). We aimed to summarize current …

Vitamin K supplementation and arterial calcification in dialysis: results of the double-blind, randomized, placebo-controlled RenaKvit trial

K Levy-Schousboe, M Frimodt-Møller… - Clinical kidney …, 2021 - academic.oup.com
Background Arterial calcification is associated with cardiovascular mortality in dialysis
patients. Active matrix Gla protein (MGP) is a vitamin K-dependent inhibitor of arterial …

[HTML][HTML] Vitamin K status and vascular calcification: evidence from observational and clinical studies

MK Shea, RM Holden - Advances in nutrition, 2012 - Elsevier
Vascular calcification occurs when calcium accumulates in the intima (associated with
atherosclerosis) and/or media layers of the vessel wall. Coronary artery calcification (CAC) …

[HTML][HTML] Vitamin K intake and status are low in hemodialysis patients

ECM Cranenburg, LJ Schurgers, HH Uiterwijk… - Kidney international, 2012 - Elsevier
Vitamin K is essential for the activity of γ-carboxyglutamate (Gla)-proteins including matrix
Gla28 protein and osteocalcin; an inhibitor of vascular calcification and a bone matrix …

[HTML][HTML] Vitamin K deficiency in CKD patients: a modifiable risk factor for vascular calcification?

T Krueger, R Westenfeld, M Ketteler, LJ Schurgers… - Kidney international, 2009 - Elsevier
The purpose of this review is to summarize currently available evidence implicating vitamin
K in the pathogenesis of vascular calcification (VC), in particular arterial medial calcification …

[HTML][HTML] Randomized controlled clinical trial of the effect of treatment with vitamin K2 on vascular calcification in hemodialysis patients (Trevasc-HDK)

S Haroon, A Davenport, LH Ling, BC Tai… - Kidney International …, 2023 - Elsevier
Introduction Vitamin K deficiency among patients on hemodialysis (HD) affects the function
of matrix GLA protein (MGP), a potent vitamin K-dependent inhibitor of vascular calcification …

Inhibiting the progression of arterial calcification with vitamin K in HemoDialysis patients (iPACK-HD) trial: rationale and study design for a randomized trial of vitamin …

RM Holden, SL Booth, AG Day… - Canadian journal of …, 2015 - journals.sagepub.com
Background: Cardiovascular disease, which is due in part to progressive vascular
calcification, is the leading cause of death among patients with end stage kidney disease …

Vitamin K for the treatment of cardiovascular disease in End-Stage Renal Disease patients: Is there hope?

S Roumeliotis, A Roumeliotis… - Current Vascular …, 2021 - ingentaconnect.com
In Chronic Kidney Disease, vascular calcification (VC) is highly prevalent even at early
stages and is gradually enhanced, along with disease progression to End-Stage Renal …

The role of vitamin K in vascular calcification of patients with chronic kidney disease

J Wuyts, A Dhondt - Acta Clinica Belgica, 2016 - Taylor & Francis
Patients with chronic kidney disease (CKD) are prone to vascular calcification. Pathogenetic
mechanisms of vascular calcifications have been broadly studied and discussed such as the …