Abstract Purpose: Regulatory T (Treg) cells are important suppressive cells among tumor-
infiltrating lymphocytes (TIL). Treg cells express the well-known immune checkpoint receptor …

Background T-cell immunoglobulin mucin 3 (TIM3) is a negative immune checkpoint and
plays a crucial part in tumor-induced immune suppression. However, the mechanism of …

T-cell immunoglobulin mucin 3 (TIM3) is an inhibitory molecule that has emerged as a key
regulator of dysfunctional or exhausted CD8+ T cells arising in chronic diseases such as …

ABSTRACT Programmed Death 1 (PD-1) and T cell Ig and mucin domain-3 protein (Tim-3)
are immune checkpoint receptors highly expressed on tumor infiltrating T lymphocytes (TIL) …

Regulatory T cells (Treg cells) are critical mediators of self-tolerance, but they can also limit
effective anti-tumor immunity. Although under homeostasis a small fraction of Treg cells in …

The paradoxical coexistence of spontaneous tumor antigen–specific immune responses
with progressive disease in cancer patients furthers the need to dissect the molecular …

Background T cell immunoglobulin-3 (TIM-3) has been established as a negative regulatory
molecule and plays a critical role in immune tolerance. TIM-3 is upregulated in exhausted …

T cell immunoglobulin mucin-3 (TIM-3) is an immune checkpoint identified as one of the key
players in regulating T-cell responses. Studies have shown that TIM-3 is upregulated in the …

Tim-3, a member of the novel Tim (T cell immunoglobulin and mucin domain) family, has
been reported to negatively regulate the immune responses against viral infection and had …

T‐cell immunoglobulin mucin 3 (TIM 3) contributes to immune suppression during
progression of many cancers, but the precise role of TIM 3 in head and neck squamous cell …