Malaria infection in humans elicits a wide range of immune responses that can be detected
in peripheral blood, but we lack detailed long-term follow-up data on the primary and …

Malaria, caused by the Plasmodium species, is an infectious disease responsible for more
than 600 thousand deaths and more than 200 million morbidity cases annually. With above …

Malaria imposes a horrific public health burden–hundreds of millions of infections and
millions of deaths–on large parts of the world. While this unacceptable health burden and its …

Severe malaria, a leading cause of mortality among children and nonimmune adults, is a
multisystemic disorder characterized by complex clinical syndromes that are mechanistically …

Recent initiatives to improve translation of findings from animal models to human disease
have focussed on reproducibility but quantifying the relevance of animal models remains a …

Plasmodium relapses are attributed to the activation of dormant liver-stage parasites and are
responsible for a significant number of recurring malaria blood-stage infections. While …

In the current study, we examined the effects of depletion of phagocytes on the progression
of Plasmodium yoelii 17XNL infection in mice. Strikingly, the depletion of phagocytic cells …

Malaria is a fatal disease that displays a spectrum of symptoms and severity, which are
determined by complex host-parasite interactions. It has been difficult to study the effects of …

Malaria is a devastating disease caused by the protozoan parasite Plasmodium. The most
common Plasmodium species that infect humans are Plasmodium falciparum and …

After transmission by Anopheles mosquitoes, Plasmodium sporozoites travel to the liver,
infect hepatocytes, and rapidly develop as intrahepatocytic liver stages (LS). Rodent models …