Abstract New pyrazolo [1, 5‐a] pyrimidines were designed and synthesized based on the
structural analysis of known CDK5 inhibitors. Biological evaluations showed that the IC50 of …

Abstract A series of pyrazolo [3, 4-d] pyrimidin-4-one scaffold were designed and
synthesized as novel CDK2 inhibitors. By analyzing the common motifs of various known …

New pyridine, pyrazoloyridine, and furopyridine derivatives substituted with naphthyl and
thienyl moieties were designed and synthesized starting from 6-(naphthalen-2-yl)-2-oxo-4 …

CDK2 is a key player in cell cycle processes. It has a crucial role in the progression of
various cancers. Hepatocellular carcinoma (HCC) and colorectal cancer (CRC) are two …

CDK2 inhibition is an appealing target for cancer treatment that targets tumor cells in a
selective manner. A new set of small molecules featuring the privileged pyrazolo [3, 4-d] …

Novel series of diphenyl-1H-pyrazoles (4a-g) and pyrazolo [3, 4-b] pyridines (5a-g and 7a-i)
were synthesized and evaluated for their antiproliferative activity against breast cancer cell …

In the current work, a hybridisation strategy was adopted between the privileged building
blocks, benzofuran and piperazine, with the aim of designing novel CDK2 type II inhibitors …

Background: Pyrazolo [3, 4-d] pyrimidine scaffold was reported to possess potent cytotoxic
and CDK2 inhibitory activity as analogue of roscovitine. Objective: To design and synthesize …

In the present work, five series of new 2, 3‐disubstituted quinazolin‐4 (3H)‐ones 4a–c, 5a–
d, 6a–g, 7a, b, and 9a–c were designed, synthesized, and screened in vitro for their cytotoxic …

In continuation of our previous work on the investigation of CDK9 inhibitors bearing indole
moiety for the discovery of novel anticancer agents, novel methylenehydrazine-1 …