Previous studies have shown that adolescent exposure to cocaine increases drug use in
adulthood, albeit incubation of cocaine seeking was found to be attenuated in rats trained to …

Rationale Age of initial exposure to addictive substances is inversely proportional to risk of
developing drug dependence. There is debate, however, as to whether intake at a young …

Human and animal laboratory studies show that females and males respond differently to
drugs and that drug administration during adolescence leads to different behavioral effects …

Adolescence marks a particularly vulnerable period to developing substance use disorders,
and people who start using drugs in adolescence are more likely to relapse. A limited …

The present experiments examined the effects of adolescent nicotine pre-exposure on the
rewarding and aversive effects of cocaine and on cocaine self-administration in adult male …

Adolescence is a transitional period during development that is associated with a greater
likelihood of addiction to drugs than any other age. One possibility for this observation is that …

Rationale and objectives Although onset of drug use during adolescence appears to
increase long-term vulnerability to drug dependence in humans, relatively little is known …

Adolescent cocaine use increases the likelihood of drug abuse and addiction in adulthood,
and etiological factors may include a cocaine-induced bias towards so-called 'reward …

As addiction is increasingly formulated as a developmental disorder, identifying how early
developmental exposures influence later responses to drugs of abuse is important to our …

Adolescent rats take cocaine more readily than adults, are more sensitive to lower doses of
the drug and work harder for it. It remains unknown if adolescent‐onset of cocaine use has …