Using a balanced conditioned place preference (CPP) paradigm, we studied the role of
protein kinases A (PKA) and C (PKC) on the acquisition, consolidation and expression of …

Rationale The place conditioning procedure is increasingly used to study relapse in drug
seeking in mice. However, the retention course of drug-induced place preference has not …

Rationale Taking high and increasing amounts of cocaine is thought to be necessary for the
development of addiction. Consequently, a widely used animal model of drug self …

Human cocaine users report that the initial “high” produced by cocaine administration is
followed by an anxiogenic “crash”. Given that cocaine has such robust and opposing …

Adverse early life events may influence vulnerability for drug intake. The influence of
handling or aversive stimulation during neonatal or adolescent periods on adult cocaine oral …

Growing evidence suggests that sex differences in cocaine reward responses are regulated
by endogenous gonadal hormones. However, few studies have addressed the role of …

We compared the effects of manipulations during week 1 vs week 2 of life on the propensity
to self-administer cocaine. Pups received daily subcutaneous saline injections, were …

Relapse to drug use following prolonged periods of abstinence results, in part, from the
ability of contextual cues paired previously with self-administered drug to elicit drug craving …

Novelty-seeking in rodents, defined as enhanced specific exploration of novel situations, is
considered to predict the response of animals to drugs of abuse and, thus, allow “drug …

Rationale Understanding the neurobehavioral mechanisms underlying dysregulated
cocaine intake is important for the development of new cocaine abuse therapies. Objectives …