Inhibitory effect of paeoniflorin on IgE-dependent and IgE-independent mast cell degranulation in vitro and vivo

Y Zhao, X Li, J Chu, Y Shao, Y Sun, Y Zhang, Z Liu - Food & Function, 2021 - pubs.rsc.org
The incidence of allergic diseases has increased to such a point that they have become
common and have reached epidemic levels. However, their pathogenesis is not fully …

Paeoniflorin inhibits IgE-mediated allergic reactions by suppressing the degranulation of mast cells though binding with FcϵRI alpha subunits

Y Zhang, S Hu, S Ge, J Wang, L He - European Journal of Pharmacology, 2020 - Elsevier
Paeoniflorin (PF), a monoterpene glycoside isolated from the aqueous extract of the
Chinese herb Radix Paeoniae Alba, has been used for treating various inflammatory …

Paeoniflorin inhibits mast cell–mediated allergic inflammation in allergic rhinitis

G Wang, N Cheng - Journal of Cellular Biochemistry, 2018 - Wiley Online Library
Paeoniflorin (PF), one of the main effective ingredients from the root of Paeonia lactiflora
Pall., was reported to possess antitumor, anti‐inflammatory, and antiallergic properties …

[HTML][HTML] Paeoniflorin attenuates the allergic contact dermatitis response via inhibiting the IFN-γ production and the NF-κB/IκBα signaling pathway in T lymphocytes

X Wu, X Qi, J Wang, Y Zhang, Y Xiao, C Tu… - International …, 2021 - Elsevier
Paeoniflorin (PF) has been demonstrated to have an anti-allergic and anti-inflammatory
effect in the treatment of allergic contact dermatitis (ACD). However, its clinical application is …

Immunoregulatory effects of paeoniflorin exerts anti-asthmatic effects via modulation of the Th1/Th2 equilibrium

T Zhang, Z Yang, S Yang, J Du, S Wang - Inflammation, 2015 - Springer
Paeoniflorin has been demonstrated to exert anti-inflammatory and immunomodulatory
effects in the animal study. In this study, we investigated immunoregulatory effects of …

Paeoniflorin inhibits MRGPRX2‐mediated pseudo‐allergic reaction via calcium signaling pathway

J Wang, Y Zhang, J Wang, R Liu, G Zhang… - Phytotherapy …, 2020 - Wiley Online Library
Mas‐related G protein‐coupled receptor‐X2 (MRGPRX2) expressed on mast cells (MCs)
has been shown to be a pivotal target for pseudo‐allergic diseases. Therefore, MRGPRX2 …

Paeoniflorin attenuates allergic inflammation in asthmatic mice

J Sun, J Wu, C Xu, Q Luo, B Li, J Dong - International …, 2015 - Elsevier
Paeoniflorin (PF), one of the major active ingredients of Chinese peony, has demonstrated
anti-inflammatory and immunoregulatory effects. However, it has remained unclear whether …

Gnetin H isolated from Paeonia anomala inhibits FcεRI-mediated mast cell signaling and degranulation

M Kim, SJ Lim, S Oidovsambuu, CW Nho - Journal of ethnopharmacology, 2014 - Elsevier
Ethnopharmacological relevance Paeonia anomala L. is used in Mongolian traditional
medicine to treat various diseases including indigestion, abdominal pain, kidney disorders …

Paeoniflorin suppresses allergic and inflammatory responses by promoting autophagy in rats with urticaria

J Guo, L Peng, J Zeng, M Zhang… - Experimental and …, 2021 - spandidos-publications.com
Paeoniflorin (PF) has been reported to be effective against several skin disorders, such as
allergic contact dermatitis and psoriasis; however, it remains unclear whether PF can protect …

Inhibitory Effects of Paeonia suffruticosa on Allergic Reactions by Inhibiting the NF-kappaB/IkappaB-alpha Signaling Pathway and Phosphorylation of ERK in an …

MH Hong, JH Kim, SH Na, H Bae… - Bioscience …, 2010 - academic.oup.com
The root cortex of Paeonia suffruticosa Andrews (PSA), also known as Moutan Cortex, is
known to have anti-allergic and anti-inflammatory properties. This study investigates the …