HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs
M Pabis, GM Popowicz, R Stehle… - Nucleic acids …, 2019 - academic.oup.com
HuR/ELAVL1 is an RNA-binding protein involved in differentiation and stress response that
acts primarily by stabilizing messenger RNA (mRNA) targets. HuR comprises three RNA …
acts primarily by stabilizing messenger RNA (mRNA) targets. HuR comprises three RNA …
The C-terminal RNA binding motif of HuR is a multi-functional domain leading to HuR oligomerization and binding to U-rich RNA targets
RM Scheiba, AI de Opakua, A Díaz-Quintana… - RNA biology, 2014 - Taylor & Francis
Human antigen R (HuR) is a 32 kDa protein with 3 RNA Recognition Motifs (RRMs), which
bind to Adenylate and uridylate Rich Elements (AREs) of mRNAs. Whereas the N-terminal …
bind to Adenylate and uridylate Rich Elements (AREs) of mRNAs. Whereas the N-terminal …
Molecular basis for AU-rich element recognition and dimerization by the HuR C-terminal RRM
N Ripin, J Boudet, MM Duszczyk… - Proceedings of the …, 2019 - National Acad Sciences
Human antigen R (HuR) is a key regulator of cellular mRNAs containing adenylate/uridylate–
rich elements (AU-rich elements; AREs). These are a major class of cis elements within 3 …
rich elements (AU-rich elements; AREs). These are a major class of cis elements within 3 …
Regulation of HuR structure and function by dihydrotanshinone-I
P Lal, L Cerofolini, VG D'Agostino, C Zucal… - Nucleic acids …, 2017 - academic.oup.com
The Human antigen R protein (HuR) is an RNA-binding protein that recognizes U/AU-rich
elements in diverse RNAs through two RNA-recognition motifs, RRM1 and RRM2, and post …
elements in diverse RNAs through two RNA-recognition motifs, RRM1 and RRM2, and post …
The x-ray crystal structure of the first RNA recognition motif and site-directed mutagenesis suggest a possible HuR redox sensing mechanism
RM Benoit, NC Meisner, J Kallen, P Graff… - Journal of molecular …, 2010 - Elsevier
Hu-antigen R (HuR) is a ubiquitous RNA-binding protein that comprises three RNA
recognition motifs (RRMs). The first two tandem RRMs are known to bind to AU-rich …
recognition motifs (RRMs). The first two tandem RRMs are known to bind to AU-rich …
[PDF][PDF] Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR
S Lebedeva, M Jens, K Theil, B Schwanhäusser… - Molecular cell, 2011 - cell.com
Posttranscriptional gene regulation relies on hundreds of RNA binding proteins (RBPs) but
the function of most RBPs is unknown. The human RBP HuR/ELAVL1 is a conserved mRNA …
the function of most RBPs is unknown. The human RBP HuR/ELAVL1 is a conserved mRNA …
Functional interplay between RNA-binding protein HuR and microRNAs
S Srikantan, K Tominaga… - Current Protein and …, 2012 - ingentaconnect.com
The mammalian RNA-binding protein (RBP) HuR associates with numerous mRNAs
encoding proteins with roles in cell division, cell survival, immune response, and …
encoding proteins with roles in cell division, cell survival, immune response, and …
HuR protein attenuates miRNA-mediated repression by promoting miRISC dissociation from the target RNA
P Kundu, MR Fabian, N Sonenberg… - Nucleic acids …, 2012 - academic.oup.com
The microRNA (miRNA)-mediated repression of protein synthesis in mammalian cells is a
reversible process. Target mRNAs with regulatory AU-rich elements (AREs) in their 3 …
reversible process. Target mRNAs with regulatory AU-rich elements (AREs) in their 3 …
[PDF][PDF] Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability
RNA-binding proteins coordinate the fates of multiple RNAs, but the principles underlying
these global interactions remain poorly understood. We elucidated regulatory mechanisms …
these global interactions remain poorly understood. We elucidated regulatory mechanisms …
HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA
S Park, DG Myszka, M Yu, SJ Littler… - Molecular and cellular …, 2000 - Taylor & Francis
Human neuron-specific RNA-binding protein HuD belongs to the family of Hu proteins and
consists of two N-terminal RNA recognition motifs (RRM1 and-2), a hinge region, and a C …
consists of two N-terminal RNA recognition motifs (RRM1 and-2), a hinge region, and a C …