miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels

K Abdelmohsen, S Srikantan… - Proceedings of the …, 2008 - National Acad Sciences
Gene expression is potently regulated through the action of RNA-binding proteins (RBPs)
and microRNAs (miRNAs). Here, we present evidence of a miRNA regulating an RBP. The …

Targeting the multifaceted HuR protein, benefits and caveats

C Zucal, V D'Agostino, R Loffredo, B Mantelli… - Current drug …, 2015 - ingentaconnect.com
The RNA-binding protein (RBP) HuR is one of the most widely studied regulators of the
eukaryotic posttranscriptional gene expression and it plays a physiological role in mediating …

Terminal adenosyl transferase activity of posttranscriptional regulator HuR revealed by confocal on-bead screening

NC Meisner, M Hintersteiner, JM Seifert… - Journal of molecular …, 2009 - Elsevier
Posttranscriptional regulation and RNA metabolism have become central topics in the
understanding of mammalian gene expression and cell signalling, with the 3′ untranslated …

Sequence requirements for RNA binding by HuR and AUF1

A Barker, MR Epis, CJ Porter… - The journal of …, 2012 - academic.oup.com
The stability of RNAs bearing AU-rich elements in their 3′-UTRs, and thus the level of
expression of their protein products, is regulated by interactions with cytoplasmic RNA …

[HTML][HTML] Global analysis of HuR-regulated gene expression in colon cancer systems of reducing complexity

IL De Silanes, J Fan, CJ Galbán, RG Spencer… - Gene …, 2004 - ncbi.nlm.nih.gov
HuR, a protein that binds to target mRNAs and can enhance their stability and translation, is
increasingly recognized as a pivotal regulator of gene expression during cell division and …

Signalling pathways regulating nucleo-cytoplasmic shuttling of the mRNA-binding protein HuR

A Doller, J Pfeilschifter, W Eberhardt - Cellular signalling, 2008 - Elsevier
During the last decade evidence from numerous studies has been accumulated
demonstrating that posttranscriptional gene regulation including mRNA turnover and …

LncRNA OIP5-AS1/cyrano sponges RNA-binding protein HuR

J Kim, K Abdelmohsen, X Yang, S De… - Nucleic acids …, 2016 - academic.oup.com
The function of the vast majority of mammalian long noncoding (lnc) RNAs remains
unknown. Here, analysis of a highly abundant mammalian lncRNA, OIP5-AS1, known as …

[HTML][HTML] Multiple functions of the RNA-binding protein HuR in cancer progression, treatment responses and prognosis

J Wang, Y Guo, H Chu, Y Guan, J Bi… - International journal of …, 2013 - mdpi.com
The human embryonic lethal abnormal vision-like protein, HuR, is a member of the Hu family
of RNA-binding proteins. Over the past decade, this ubiquitously expressed protein has …

Identification and validation of novel small molecule disruptors of HuR-mRNA interaction

X Wu, L Lan, DM Wilson, RT Marquez… - ACS chemical …, 2015 - ACS Publications
HuR, an RNA binding protein, binds to adenine-and uridine-rich elements (ARE) in the 3′-
untranslated region (UTR) of target mRNAs, regulating their stability and translation. HuR is …

The RNA-binding protein RNPC1 stabilizes the mRNA encoding the RNA-binding protein HuR and cooperates with HuR to suppress cell proliferation

SJ Cho, YS Jung, J Zhang, X Chen - Journal of Biological Chemistry, 2012 - ASBMB
The RNA-binding protein HuR, a member of the embryonic lethal abnormal vision/Hu
protein family, plays a critical role in many cellular processes, including cell proliferation …