Capsaicin analogues are typically synthetized by condensation of the amide group of
vanillylamine with a fatty acid derivative. The enzyme of choice to perform this reaction is …

Capsaicin was hydrolysed by lipase B from Candida antarctica into vanillylamine and 8-
methyl-6-trans-nonenoic acid. Conversions of 70% were obtained after 72 h at 70° C in …

Various lipases catalyzed the synthesis of capsaicin analogs by amidation of vanillylamine
with fatty acid derivatives in a two-phase system. When methyl myristate was employed as …

Synthesis of capsaicin analogs using natural oils as an acyl donor has been achieved by
condensation with vanillylamine using Lipase D, Lipase R or Novozym 435 as a catalyst …

Despite the proven therapeutic role of capsaicin in human health, its usage is still hampered
by its high pungency. In this sense, nonpungent capsaicin analogues as olvanil are a …

Transacylation of capsaicin with triolein using a commercial lipase gave olvanil in an 85%
yield at 70° C for 144 h. When olive oil was employed, the major product was olvanil (62%) …

Candida antarctica lipase fraction B (CAL-B) showed substrate specificity in the synthesis of
esters in hexane involving reactions of short-chain acids having linear (acetic and butyric …

Capsiate has a structure similar to capsaicin but no oral pungency. Furthermore, capsiate
displayed antioxidant activity and inhibited angiogenesis and vascular permeability, and …

Several flavonoids (quercetin, hesperidin, rutin and esculin) were acylated with fatty acids
using an immobilised lipase from Candida antarctica in 2-methyl-2-butanol at 60° C. It …

The hydrolytic activity of Candida antarctica lipase B (CAL-B) was studied using 15 amides
with different linear saturated acyl residues and substituents in the aromatic amine. A strong …