Purpose: Glioblastoma, a common malignant intracranial tumor, has the most dismal
prognosis. Autophagy was reported to act as a survival-promoting mechanism in gliomas by …

Glioblastoma (GBM) is one of the most malignant and aggressive primary brain tumor, with a
mean life expectancy of less than 15 months. The malignant nature of GBM prompts the …

Autophagy is a process essential for cellular energy consumption, survival, and defense
mechanisms. The role of autophagy in several types of human cancers has been explicitly …

Epithelial-to-mesenchymal transition (EMT) and its reverse process MET naturally occur
during development and in tissue repair in vertebrates. EMT is also recognized as the …

Background Glioblastoma multiforme (GBM) is characterized by lethal aggressiveness and
patients with GBM are in urgent need for new therapeutic avenues to improve quality of life …

Glioblastoma multiforme (GBM) is the most common and aggressive type of primary brain
tumor in adults, with a poor median survival of approximately 15 months after diagnosis …

Autophagy is an evolutionarily conserved catabolic process that plays an essential role in
maintaining cellular homeostasis by degrading unneeded cell components. When exposed …

Glioblastoma is the most common and aggressive adult brain tumour, with poor median
survival and limited treatment options. Following surgical resection and chemotherapy …

The function of macroautophagy/autophagy during tumor initiation or in established tumors
can be highly distinct and context-dependent. To investigate the role of autophagy in …

Cell migration and invasion are highly regulated processes involved in both physiological
and pathological conditions. Here we show that autophagy modulation regulates the …