The effects of kahweol, a diterpene present in coffee, on the mitochondria of the human neuroblastoma SH-SY5Y cells exposed to hydrogen peroxide
CR Fürstenau, ICC de Souza, MR de Oliveira - Toxicology in Vitro, 2019 - Elsevier
The oxidative phosphorylation (OXPHOS) system located in the mitochondria is the main
source of adenosine triphosphate (ATP) in mammals. The mitochondria are also the main …
source of adenosine triphosphate (ATP) in mammals. The mitochondria are also the main …
Mitochondrial protection promoted by the coffee diterpene kahweol in methylglyoxal-treated human neuroblastoma SH-SY5Y cells
MR de Oliveira, ICC de Souza, CR Fürstenau - Neurotoxicity Research, 2020 - Springer
The coffee diterpene kahweol (KW; C 20 H 26 O 3) is a cytoprotective agent exhibiting
potent antioxidant actions, as demonstrated in several experimental models. In spite of the …
potent antioxidant actions, as demonstrated in several experimental models. In spite of the …
Mitochondrial protection and anti-inflammatory effects induced by emodin in the human neuroblastoma SH-SY5Y cells exposed to hydrogen peroxide: Involvement of …
MR de Oliveira, ICC de Souza, FB Brasil - Neurochemical Research, 2021 - Springer
Abstract Emodin (EM; 1, 3, 8-trihydroxy-6-methylanthracene-9, 10-dione; C 15 H 10 O 5) is
an anthraquinone and exerts cytoprotective effects, as observed in both in vitro and in vivo …
an anthraquinone and exerts cytoprotective effects, as observed in both in vitro and in vivo …
[HTML][HTML] The signaling pathway PI3K/Akt/Nrf2/HO-1 plays a role in the mitochondrial protection promoted by astaxanthin in the SH-SY5Y cells exposed to hydrogen …
FB Brasil, RCB Gobbo, FJS de Almeida… - Neurochemistry …, 2021 - Elsevier
The mitochondria are the major source of reactive species in the mammalian cells.
Hydrogen peroxide (H 2 O 2) is a potent inducer of redox impairment by a mechanism, at …
Hydrogen peroxide (H 2 O 2) is a potent inducer of redox impairment by a mechanism, at …
Pretreatment of MQA, a caffeoylquinic acid derivative compound, protects against H2O2-induced oxidative stress in SH-SY5Y cells
X Tian, L Gao, L An, X Jiang, J Bai, J Huang… - Neurological …, 2016 - Taylor & Francis
Objectives: Compound MQA (1, 5-O-dicaffeoyl-3-O-[4-malic acid methyl ester]-quinic acid) is
a natural caffeoylquinic acid derivative isolated from Arctium lappa L. roots. This study aims …
a natural caffeoylquinic acid derivative isolated from Arctium lappa L. roots. This study aims …
Inhibition of the Nrf2/HO-1 axis suppresses the mitochondria-related protection promoted by gastrodin in human neuroblastoma cells exposed to paraquat
MR de Oliveira, F de Bittencourt Brasil… - Molecular …, 2019 - Springer
Mitochondria are double-membrane organelles involved in the transduction of energy from
different metabolic substrates into adenosine triphosphate (ATP) in mammalian cells. The …
different metabolic substrates into adenosine triphosphate (ATP) in mammalian cells. The …
Promotion of mitochondrial protection by naringenin in methylglyoxal-treated SH-SY5Y cells: Involvement of the Nrf2/GSH axis
MR de Oliveira, ICC de Souza, CR Fürstenau - Chemico-biological …, 2019 - Elsevier
Disruption of the mitochondrial function has been associated with redox impairment and
triggering of cell death in nucleated human cells, as observed in several diseases. The …
triggering of cell death in nucleated human cells, as observed in several diseases. The …
Carvacrol depends on heme oxygenase-1 (HO-1) to exert antioxidant, anti-inflammatory, and mitochondria-related protection in the human neuroblastoma SH-SY5Y …
AL Chenet, AR Duarte, FJS de Almeida… - Neurochemical …, 2019 - Springer
The link between mitochondrial dysfunction, redox impairment, and inflammation leads to
increased rates of brain cells loss in neurodegenerative diseases and in affective disorders …
increased rates of brain cells loss in neurodegenerative diseases and in affective disorders …
Punicalagin reduces H2O2-induced cytotoxicity and apoptosis in PC12 cells by modulating the levels of reactive oxygen species
Background: Oxidative stress has long been linked to neuronal cell death in many
neurodegenerative diseases. Antioxidant conventional supplements are poorly effective in …
neurodegenerative diseases. Antioxidant conventional supplements are poorly effective in …
[HTML][HTML] The coffee diterpene kahweol induces heme oxygenase-1 via the PI3K and p38/Nrf2 pathway to protect human dopaminergic neurons from 6 …
YP Hwang, HG Jeong - FEBS letters, 2008 - Elsevier
In this study, we investigated the mechanisms of kahweol protection of neuronal cells from
cell death induced by the Parkinson's disease-related neurotoxin 6-hydroxydopamine (6 …
cell death induced by the Parkinson's disease-related neurotoxin 6-hydroxydopamine (6 …