Genetic contributions to transdiagnostic symptom dimensions in patients with major depressive disorder, bipolar disorder, and schizophrenia spectrum disorders
Major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia spectrum
disorders (SZ) exhibit considerable phenotypic and genetic overlap. However, the …
disorders (SZ) exhibit considerable phenotypic and genetic overlap. However, the …
Melancholic features and typical neurovegetative symptoms of major depressive disorder show specific polygenic patterns
Background Major depressive disorder (MDD) is a highly prevalent psychiatric condition
characterised by a heterogeneous clinical presentation and an estimated twin-based …
characterised by a heterogeneous clinical presentation and an estimated twin-based …
Multi‐polygenic scores in psychiatry: From disorder specific to transdiagnostic perspectives
The dense co‐occurrence of psychiatric disorders questions the categorical classification
tradition and motivates efforts to establish dimensional constructs with neurobiological …
tradition and motivates efforts to establish dimensional constructs with neurobiological …
Isolating transdiagnostic effects reveals specific genetic profiles in psychiatric disorders
Evidence indicates a great degree of genetic overlap between psychiatric diagnoses.
Accounting for these transdiagnostic effects can sharpen research on disorder-specific …
Accounting for these transdiagnostic effects can sharpen research on disorder-specific …
A comparison of depressive symptom profiles between current major depressive disorder and schizophrenia spectrum disorder
SMM Lange, F Schirmbeck, ML Stek… - Journal of psychiatric …, 2021 - Elsevier
Introduction Depressive symptoms are highly prevalent and clinically relevant in
schizophrenia spectrum disorder (SSD) patients. So far, little is known about to what extent …
schizophrenia spectrum disorder (SSD) patients. So far, little is known about to what extent …
Association of neurotransmitter pathway polygenic risk with specific symptom profiles in psychosis
A primary goal of psychiatry is to better understand the pathways that link genetic risk to
psychiatric symptoms. Here, we tested association of diagnosis and endophenotypes with …
psychiatric symptoms. Here, we tested association of diagnosis and endophenotypes with …
Dissection of major depressive disorder using polygenic risk scores for schizophrenia in two independent cohorts
Major depressive disorder (MDD) is known for its substantial clinical and suspected causal
heterogeneity. It is characterized by low mood, psychomotor slowing and increased levels of …
heterogeneity. It is characterized by low mood, psychomotor slowing and increased levels of …
Using clinical characteristics to identify which patients with major depressive disorder have a higher genetic load for three psychiatric disorders
J Verduijn, Y Milaneschi, WJ Peyrot, JJ Hottenga… - Biological …, 2017 - Elsevier
Background Limited successes of gene finding for major depressive disorder (MDD) may be
partly due to phenotypic heterogeneity. We tested whether the genetic load for MDD, bipolar …
partly due to phenotypic heterogeneity. We tested whether the genetic load for MDD, bipolar …
[HTML][HTML] Polygenic Analyses Show Important Differences Between Major Depressive Disorder Symptoms Measured Using Various Instruments
Background Symptoms of major depressive disorder (MDD) are commonly assessed using
self-rating instruments like the Patient Health Questionnaire-9 (PHQ-9)(current symptoms) …
self-rating instruments like the Patient Health Questionnaire-9 (PHQ-9)(current symptoms) …
Key subphenotypes of bipolar disorder are differentially associated with polygenic liabilities for bipolar disorder, schizophrenia, and major depressive disorder
Bipolar disorder (BD) features heterogenous clinical presentation and course of illness. It
remains unclear how subphenotypes associate with genetic loadings of BD and related …
remains unclear how subphenotypes associate with genetic loadings of BD and related …