The tricarboxylic acid (TCA) cycle is a central hub of cellular metabolism, oxidizing nutrients
to generate reducing equivalents for energy production and critical metabolites for …

Activated CD4 T cells proliferate rapidly and remodel epigenetically before exiting the cell
cycle and engaging acquired effector functions. Metabolic reprogramming from the naive …

Cultured pluripotent stem cells are a cornerstone of regenerative medicine owing to their
ability to give rise to all cell types of the body. Although pluripotent stem cells can be …

The tricarboxylic acid (TCA) cycle, otherwise known as the Krebs cycle, is a central
metabolic pathway that performs the essential function of oxidizing nutrients to support …

A major question remaining in the field of evolutionary biology is how prokaryotic organisms
made the leap to complex eukaryotic life. The prevailing theory depicts the origin of …

DNA microarray studies have shown that hundreds of genes are transcribed periodically
during the mitotic cell cycle of humans, budding yeast,, fission yeast,, and the plant …

It has recently been shown that in anaerobic microorganisms the tricarboxylic acid (TCA)
cycle, including the seemingly irreversible citrate synthase reaction, can be reversed and …

Mitochondria are signaling organelles that regulate a wide variety of cellular functions and
can dictate cell fate. Multiple mechanisms contribute to communicate mitochondrial fitness to …

Postnatal maturation of cardiomyocytes is characterized by a metabolic switch from
glycolysis to fatty acid oxidation, chromatin reconfiguration and exit from the cell cycle …

Whether post-transcriptional regulation of gene expression controls differentiation of stem
cells for tissue renewal remains unknown. Quiescent stem cells exhibit a low level of protein …