Mammalian embryogenesis requires rapid growth and proper metabolic regulation.
Midgestation features increasing oxygen and nutrient availability concomitant with fetal …

CD4+ T cell differentiation requires metabolic reprogramming to fulfil the bioenergetic
demands of proliferation and effector function, and enforce specific transcriptional …

The tricarboxylic acid (TCA) cycle, a crucial component of respiratory metabolism, is
composed of a set of eight enzymes present in the mitochondrial matrix. However, most of …

The role of cellular metabolism in regulating cell proliferation and differentiation remains
poorly understood. For example, most mammalian cells cannot proliferate without …

How adult tissue stem and niche cells respond to the nutritional state of an organism is not
well understood. Here we find that Paneth cells, a key constituent of the mammalian …

Mitochondria are involved in a variety of cellular functions, including ATP production, amino
acid and lipid biogenesis and breakdown, signalling and apoptosis,,. Mitochondrial …

Mitochondrial metabolism provides precursors to build macromolecules in growing cancer
cells,. In normally functioning tumour cell mitochondria, oxidative metabolism of glucose-and …

The house mouse (Mus musculus) is an exceptional model system, combining genetic
tractability with close evolutionary affinity to humans,. Mouse gestation lasts only 3 weeks …

Understanding cell state transitions and purposefully controlling them is a longstanding
challenge in biology. Here we present cell state transition assessment and regulation …

Most cells contain the same set of genes and yet they are extremely diverse in appearance
and functions. It is the selective expression and repression of genes that determines the …