Abstract TET (ten-eleven-translocation) proteins are Fe (ii)-and α-ketoglutarate-dependent
dioxygenases,, that modify the methylation status of DNA by successively oxidizing 5 …

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Cellular differentiation involves profound remodelling of chromatic landscapes, yet the
mechanisms by which somatic cell identity is subsequently maintained remain incompletely …

Cellular reprogramming can manipulate the identity of cells to generate the desired cell
types,–. The use of cell intrinsic components, including oocyte cytoplasm and transcription …

Pluripotency is defined by the ability of a cell to differentiate to the derivatives of all the three
embryonic germ layers: ectoderm, mesoderm and endoderm. Pluripotent cells can be …

The pace of human brain development is highly protracted compared with most other
species,,,,,–. The maturation of cortical neurons is particularly slow, taking months to years to …

172| NATURE| VOL 563| 8 NOVEMBER 2018© 2018 Springer Nature Li mited. All rights
reserved. here were just eight ingredients: two proteins, three buffering agents, two types of …

Obesity increases the risk of mortality because of metabolic sequelae such as type 2
diabetes and cardiovascular disease. Thermogenesis by adipocytes can counteract obesity …

Oxidative phosphorylation (OXPHOS) is a vital process for energy generation, and is carried
out by complexes within the mitochondria. OXPHOS complexes pose a unique challenge for …

The tricarboxylic acid (TCA) cycle is a primordial metabolic pathway that is conserved from
bacteria to humans. Although this network is often viewed primarily as an energy producing …