In eukaryotes, the anaphase-promoting complex (APC/C, also known as the cyclosome)
regulates the ubiquitin-dependent proteolysis of specific cell-cycle proteins to coordinate …

Totipotency emerges in early embryogenesis, but its molecular underpinnings remain poorly
characterized. In the present study, we employed DNA fiber analysis to investigate how …

We recently discovered an unexpected phenomenon of somatic cell reprogramming into
pluripotent cells by exposure to sublethal stimuli, which we call stimulus-triggered …

Embryonic stem cells (ESCs) manifest a unique metabolism that is intimately linked to their
pluripotent state. In this issue, Moussaieff et al.(2015) find that ESCs utilize glycolysis to fuel …

During pre-implantation development, the mammalian embryo self-organizes into the
blastocyst, which consists of an epithelial layer encapsulating the inner-cell mass (ICM) …

Self-renewal of rodent embryonic stem cells is enhanced by partial inhibition of glycogen
synthase kinase-3 (Gsk3; refs,). This effect has variously been attributed to stimulation of Wnt …

Transitioning from pluripotency to differentiated cell fates is fundamental to both embryonic
development and adult tissue homeostasis. Improving our understanding of this transition …

AN as-yet unresolved issue in developmental neurobiology is whether the discrete areas
that form the mammalian cortex emerge from a uniform cortical plate or whether they are …

The entry of mammalian cells into the DNA synthesis phase (S phase) represents a key
event in cell division. According to current models of the cell cycle, the kinase CDC7 …

During early fasting, increases in skeletal muscle proteolysis liberate free amino acids for
hepatic gluconeogenesis in response to pancreatic glucagon. Hepatic glucose output …