Diabetes mellitus is prevalent among women of reproductive age, and many women are left
undiagnosed or untreated. Gestational diabetes has profound and enduring effects on the …

Totipotent cells have the ability to generate embryonic and extra-embryonic tissues.
Interestingly, a rare population of cells with totipotent-like potential, known as 2 cell (2C)-like …

Many organisms can enter a dormant state or diapause to survive harsh environmental
conditions for extended durations. When Caenorhabditis elegans larvae enter dauer they …

Measurements of the abundance of common metabolites in cultured embryonic stem (ES)
cells revealed an unusual state with respect to one-carbon metabolism. These findings led …

In eukaryotes, the activation of mitotic cyclin-dependent kinases (CDKs) induces mitosis,
and their inactivation causes cells to leave mitosis. In budding yeast, two redundant …

Reprogramming of mitochondria provides cells with the metabolic flexibility required to
adapt to various developmental transitions such as stem cell activation or immune cell …

Aging is accompanied by a general decline in the function of many cellular pathways.
However, whether these are causally or functionally interconnected remains elusive. Here …

The ability of proteins and nucleic acids to undergo liquid–liquid phase separation has
recently emerged as an important molecular principle of how cells rapidly and reversibly …

The scope and variety of the metabolic intermediates from the mitochondrial tricarboxylic
acid (TCA) cycle that are engaged in epigenetic regulation of the chromatin function in the …

Cyclin degradation is central to regulation of the cell cycle. Mitotic exit was proposed to
require degradation of the S phase cyclin Clb5 by the anaphase-promoting complex …