Brain angiotensinergic regulation of the immune system: implications for cardiovascular and neuroendocrine responses

M Iovino, T Messana, G De Pergola… - … Metabolic & Immune …, 2020 - ingentaconnect.com
Objective: The Renin-Angiotensin-Aldosterone System (RAAS) plays a major role in the
regulation of cardiovascular functions, water and electrolytic balance, and hormonal …

Interactions of the brain renin-angiotensin-system (RAS) and inflammation in the sensitization of hypertension

B Xue, Y Zhang, AK Johnson - Frontiers in Neuroscience, 2020 - frontiersin.org
Mounting evidence indicates that the renin-angiotensin (RAS) and immune systems interact
with one another in the central nervous system (CNS) and that they are importantly involved …

Brain areas involved in modulating the immune response participating in hypertension and its target organ damage

M Perrotta, D Carnevale - Antioxidants & Redox Signaling, 2021 - liebertpub.com
Significance: Hypertension is a multifactorial disease ensuing from the continuous challenge
imposed by several risk factors on the cardiovascular system. Classically known …

Inflammation and neurogenic hypertension: a new role for the circumventricular organs?

E Lazartigues - Circulation research, 2010 - Am Heart Assoc
The brain renin–angiotensin system (RAS) plays a critical role in maintaining blood pressure
regulation and volume homeostasis. Components of the RAS, including angiotensinogen …

The neurology of hypertension: merging academic specialties to connect heart and brain pathophysiology

G Lembo, M Perrotta - 2021 - academic.oup.com
The brain is the main regulator of blood pressure (BP) homeostasis, yet it is a target organ of
the injury induced by acute and chronic BP alterations, like hypertension and hypotension …

Angiotensin II and the cardiac parasympathetic nervous system in hypertension

J Shanks, R Ramchandra - International journal of molecular sciences, 2021 - mdpi.com
The renin–angiotensin–aldosterone system (RAAS) impacts cardiovascular homeostasis via
direct actions on peripheral blood vessels and via modulation of the autonomic nervous …

The central nervous system and inflammation in hypertension

PJ Marvar, H Lob, A Vinh, F Zarreen… - Current opinion in …, 2011 - Elsevier
In recent years a major research effort has focused on the role of inflammation, and in
particular adaptive immunity, in the genesis of hypertension. Hypertension stimulates the …

Neuroimmune communication in hypertension and obesity: a new therapeutic angle?

AD de Kloet, EG Krause, PD Shi, J Zubcevic… - Pharmacology & …, 2013 - Elsevier
Hypertension is an epidemic health concern and a major risk factor for the development of
cardiovascular disease. Although there are available treatment strategies for hypertension …

The renin-angiotensin system and the brain

M Molina-Van den Bosch, C Jacobs-Cachá… - … y Riesgo Vascular, 2021 - europepmc.org
The renin-angiotensin-aldosterone (RAAS) system and its effects on blood pressure and the
regulation of water and electrolyte balance have been studied focusing on the …

Compromised blood–brain barrier permeability: novel mechanism by which circulating angiotensin II signals to sympathoexcitatory centres during hypertension

VC Biancardi, JE Stern - The Journal of physiology, 2016 - Wiley Online Library
Angiotensin II (AngII) is a pivotal peptide implicated in the regulation of blood pressure. In
addition to its systemic vascular and renal effects, AngII acts centrally to modulate the …