Evaluating germline testing panels in southern African males with advanced prostate cancer

K Gheybi, J Jiang, SBA Mutambirwa, PXY Soh… - Journal of the National …, 2023 - jnccn.org
Background: Germline testing for prostate cancer is on the increase, with clinical
implications for risk assessment, treatment, and management. Regardless of family history …

Germline variant spectrum among African American men undergoing prostate cancer germline testing: need for equity in genetic testing

VN Giri, R Hartman, M Pritzlaff, C Horton… - JCO Precision …, 2022 - ascopubs.org
PURPOSE Guidelines for prostate cancer (PCA) germline testing (GT) have expanded, with
impact on clinical management and hereditary cancer assessment. African American (AA) …

Evaluation of a mainstream model of genetic testing for men with prostate cancer

T Scheinberg, A Goodwin, E Ip, A Linton, B Mak… - JCO Oncology …, 2021 - ascopubs.org
PURPOSE: To identify the approximately 12% with inherited cancer predisposition, all men
with metastatic prostate cancer (mPC) should be offered germline genetic testing. This …

[引用][C] Germline testing for men with prostate cancer: navigating an expanding new world of genetic evaluation for precision therapy and precision management

VN Giri, C Hyatt, LG Gomella - Journal of Clinical Oncology, 2019 - ascopubs.org
Germline genetic testing is revolutionizing prostate cancer (PCA) care, with studies
revealing inherited mutations (pathogenic variants) in a spectrum of cancer risk genes. 1-5 …

Whole-genome sequencing reveals elevated tumor mutational burden and initiating driver mutations in African men with treatment-naïve, high-risk prostate cancer

W Jaratlerdsiri, EKF Chan, T Gong, DC Petersen… - Cancer research, 2018 - AACR
African-American men are more likely than any other racial group to die from prostate
cancer. The contribution of acquired genomic variation to this racial disparity is largely …

Implementation of germline testing for prostate cancer: Philadelphia Prostate Cancer Consensus Conference 2019

VN Giri, KE Knudsen, WK Kelly, HH Cheng… - Journal of Clinical …, 2020 - ascopubs.org
PURPOSE Germline testing (GT) is a central feature of prostate cancer (PCA) treatment,
management, and hereditary cancer assessment. Critical needs include optimized …

Germline genetic testing in advanced prostate cancer; practices and barriers: survey results from the Germline Genetics Working Group of the Prostate Cancer Clinical …

CJ Paller, ES Antonarakis, TM Beer, HT Borno… - Clinical genitourinary …, 2019 - Elsevier
Background Germline genetic testing increasingly identifies advanced prostate cancer
(PCa) patients who are candidates for precision therapies. The Prostate Cancer Clinical …

Aligning germline and somatic mutations in prostate cancer. Are genetics changing practice?

O Cussenot, G Cancel‐Tassin, SR Rao… - BJU …, 2023 - Wiley Online Library
Objective To review the current status of germline and somatic (tumour) genetic testing for
prostate cancer (PCa), and its relevance for clinical practice. Methods A narrative synthesis …

[HTML][HTML] Recommendations for the implementation of genetic testing for metastatic prostate cancer patients in Canada

S Selvarajah, KA Schrader, MP Kolinsky… - Canadian Urological …, 2022 - ncbi.nlm.nih.gov
Methods A multidisciplinary steering committee guided the process of an environmental
scan to define the current landscape, as well as the perceived challenges, through …

[HTML][HTML] Genetic aspects and molecular testing in prostate cancer: a report from a Dutch multidisciplinary consensus meeting

N Mehra, I Kloots, M Vlaming, S Aluwini… - European urology open …, 2023 - Elsevier
Background Germline and tumour genetic testing in prostate cancer (PCa) is becoming
more broadly accepted, but testing indications and clinical consequences for carriers in …