Bringing prostate cancer germline genetics into clinical practice
Purpose: Until recently the role of germline genetics in prostate cancer care was not well
defined. While important questions remain, we reviewed the current understanding of …
defined. While important questions remain, we reviewed the current understanding of …
[HTML][HTML] Understanding the uptake and challenges of genetic testing guidelines for prostate cancer patients
Background Multiple studies have confirmed a high prevalence of prognostic germline
mutations in prostate cancer. In recognition, the NCCN guidelines and recommendations for …
mutations in prostate cancer. In recognition, the NCCN guidelines and recommendations for …
[HTML][HTML] Prostate cancer in Southern Africa: does Africa hold untapped potential to add value to the current understanding of a common disease?
VM Hayes, MSR Bornman - Journal of Global Oncology, 2018 - ncbi.nlm.nih.gov
Prostate cancer (PCa) is the most common cancer diagnosis in men from economically
stable countries and is a leading cause of cancer-related death. 1 However, the population …
stable countries and is a leading cause of cancer-related death. 1 However, the population …
Gene-based confirmatory germline testing following tumor-only sequencing of prostate cancer
Background Tumor-only genomic profiling is an important tool in therapeutic management of
men with prostate cancer. Since clinically actionable germline variants may be reflected in …
men with prostate cancer. Since clinically actionable germline variants may be reflected in …
A pilot study of clinical targeted next generation sequencing for prostate cancer: consequences for treatment and genetic counseling
HH Cheng, N Klemfuss, B Montgomery… - The …, 2016 - Wiley Online Library
BACKGROUND Targeted next generation sequencing (tNGS) is increasingly used in
oncology for therapeutic decision‐making, but is not yet widely used for prostate cancer. The …
oncology for therapeutic decision‐making, but is not yet widely used for prostate cancer. The …
Genomic profiling of prostate cancers from men with African and European ancestry
Abstract Purpose: African American (AFR) men have the highest mortality rate from prostate
cancer (PCa) compared with men of other racial/ancestral groups. Differences in the …
cancer (PCa) compared with men of other racial/ancestral groups. Differences in the …
Observed evidence for guideline‐recommended genes in predicting prostate cancer risk from a large population‐based cohort
Background Germline testing for prostate cancer (PCa) is now recommended by the
National Comprehensive Cancer Network. While multi‐gene testing has been proposed …
National Comprehensive Cancer Network. While multi‐gene testing has been proposed …
Addition of germline testing to tumor-only sequencing improves detection of pathogenic germline variants in men with advanced prostate cancer
JE Berchuck, D Boiarsky, R Silver, R Sunkara… - JCO Precision …, 2022 - ascopubs.org
PURPOSE Guidelines recommend somatic and germline testing for men with advanced
prostate cancer (PCa). Barriers to widespread implementation result in underutilization of …
prostate cancer (PCa). Barriers to widespread implementation result in underutilization of …
Inherited mutations in Chinese men with prostate cancer
Background: Although China accounts for 7.8% of worldwide new prostate cancer (PCa)
cases and 14.5% of new deaths according to GLOBOCAN 2020, the risk of PCa associated …
cases and 14.5% of new deaths according to GLOBOCAN 2020, the risk of PCa associated …
Rare germline mutations in African American men diagnosed with early‐onset prostate cancer
JL Beebe‐Dimmer, KA Zuhlke, AM Johnson… - The …, 2018 - Wiley Online Library
Background African Americans have both a higher incidence of prostate cancer and greater
disease‐specific mortality compared with non‐Hispanic whites. Historically, the investigation …
disease‐specific mortality compared with non‐Hispanic whites. Historically, the investigation …