Advances, challenges, and perspectives in translational stem cell therapy for amyotrophic lateral sclerosis

E Abati, N Bresolin, G Comi, S Corti - Molecular Neurobiology, 2019 - Springer
Finding an effective therapeutic approach is a primary goal for current and future research
for amyotrophic lateral sclerosis (ALS), a fatal neurological disease characterized by …

Stem cell transplantation for amyotrophic lateral sclerosis: therapeutic potential and perspectives on clinical translation

I Faravelli, G Riboldi, M Nizzardo, C Simone… - Cellular and molecular …, 2014 - Springer
Amyotrophic lateral sclerosis (ALS) is a fatal neurological disease characterized by
degeneration of upper and lower motor neurons. There are currently no clinically impactful …

Stem cells in amyotrophic lateral sclerosis: motor neuron protection or replacement?

V Silani, C Calzarossa, L Cova… - CNS & Neurological …, 2010 - ingentaconnect.com
Given the lack of effective drug treatments for amyotrophic lateral sclerosis (ALS),
compelling preclinical data on stem cell research has targeted this disease as a candidate …

Amyotrophic lateral sclerosis: applications of stem cells–an update

L Cova, V Silani - Stem cells and cloning: advances and …, 2010 - Taylor & Francis
Neurodegenerative diseases are a growing public health challenge, and amyotrophic lateral
sclerosis (ALS) remains a fatal incurable disease. The advent of stem cell therapy has …

Translational stem cell therapy for amyotrophic lateral sclerosis

NM Boulis, T Federici, JD Glass, JS Lunn… - Nature Reviews …, 2012 - nature.com
Effective treatments are urgently needed for amyotrophic lateral sclerosis (ALS), a fatal
neurodegenerative disease characterized by the loss of motor neurons. In 2009, the FDA …

Advances, challenges and future directions for stem cell therapy in amyotrophic lateral sclerosis

Y Ciervo, K Ning, X Jun, PJ Shaw, RJ Mead - Molecular …, 2017 - Springer
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative condition
where loss of motor neurons within the brain and spinal cord leads to muscle atrophy …

Concise review: Stem cell therapies for amyotrophic lateral sclerosis: recent advances and prospects for the future

JS Lunn, SA Sakowski, EL Feldman - Stem cells, 2014 - academic.oup.com
Amyotrophic lateral sclerosis (ALS) is a lethal disease involving the loss of motor neurons.
Although the mechanisms responsible for motor neuron degeneration in ALS remain …

Advances in stem cell therapy for amyotrophic lateral sclerosis

L Mazzini, D Ferrari, PR Andjus… - Expert opinion on …, 2018 - Taylor & Francis
ABSTRACT Introduction: Amyotrophic Lateral Sclerosis (ALS) is a progressive, incurable
neurodegenerative disease that targets motoneurons. Cell-based therapies have generated …

[HTML][HTML] The past, present and future of stem cell clinical trials for ALS

GM Thomsen, G Gowing, S Svendsen… - Experimental …, 2014 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder that is
characterized by progressive degeneration of motor neurons in the cortex, brainstem and …

[HTML][HTML] Recent advances and the future of stem cell therapies in amyotrophic lateral sclerosis

SA Goutman, KS Chen, EL Feldman - Neurotherapeutics, 2015 - Elsevier
Amyotrophic lateral sclerosis is a progressive neurodegenerative disease of the motor
neurons without a known cure. Based on the possibility of cellular neuroprotection and early …