Neuropathic pain is a debilitating disease which affects central as well as peripheral
nervous system. Transient receptor potential (TRP) channels are ligand-gated ion channels …

Patients with inflammatory or neuropathic pain experience hypersensitivity to mechanical,
thermal and/or chemical stimuli. Given the diverse etiologies and molecular mechanisms of …

Thermal and noxious stimuli are detected by specialized nerve endings, which transform the
stimuli into electrical signals and transmit the signals into central nervous system to facilitate …

Highlights•Neuropathic pain is a chronic condition that represents a major health
problem.•There is a need for new medications with greater efficacy and less adverse …

Transient receptor potential (TRP) ion channels are molecular gateways in sensory systems,
an interface between the environment and the nervous system. Several TRPs transduce …

Preclinical research has identified an array of ion channels in sensory neurons involved in
the generation and transduction of pain as potential targets for pharmacological intervention …

Historically, drug research targeted to pain treatment has focused on trying to prevent the
propagation of action potentials in the periphery from reaching the brain rather than …

Preclinical research has recently uncovered new molecular mechanisms underlying the
generation and transduction of pain, many of which represent opportunities for …

It is crucial for a living organism to recognize and discern potentially harmful noxious stimuli
from innocuous stimuli to avoid hazards in the environment. However, unnecessary or …

Nociception is the process of transmission of painful signals by nociceptors in the primary
afferent nerve fibers, which specifically respond to noxious stimuli. These noxious stimuli are …