The sugar code: letters and vocabulary, writers, editors and readers and biosignificance of functional glycan–lectin pairing

H Kaltner, J Abad-Rodríguez, AP Corfield… - Biochemical …, 2019 - portlandpress.com
Ubiquitous occurrence in Nature, abundant presence at strategically important places such
as the cell surface and dynamic shifts in their profile by diverse molecular switches qualifies …

A guide into glycosciences: how chemistry, biochemistry and biology cooperate to crack the sugar code

D Solis, NV Bovin, AP Davis, J Jiménez-Barbero… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Background The most demanding challenge in research on molecular aspects within the
flow of biological information is posed by the complex carbohydrates (glycan part of cellular …

From lectin structure to functional glycomics: principles of the sugar code

HJ Gabius, S André, J Jiménez-Barbero… - Trends in biochemical …, 2011 - cell.com
Lectins are carbohydrate-binding proteins which lack enzymatic activity on their ligand and
are distinct from antibodies and free mono-and oligosaccharide sensor/transport proteins …

Lectins: getting familiar with translators of the sugar code

S André, H Kaltner, JC Manning, PV Murphy… - Molecules, 2015 - mdpi.com
The view on the significance of the presence of glycans in glycoconjugates is undergoing a
paradigmatic change. Initially mostly considered to be rather inert and passive, the concept …

Towards defining the role of glycans as hardware in information storage and transfer: basic principles, experimental approaches and recent progress

D Solís, J Jiménez-Barbero, H Kaltner, A Romero… - Cells Tissues …, 2001 - karger.com
The term 'code'in biological information transfer appears to be tightly and hitherto exclusively
connected with the genetic code based on nucleotides and translated into functional …

Glycans: bioactive signals decoded by lectins

HJ Gabius - Biochemical Society Transactions, 2008 - portlandpress.com
The glycan part of cellular glycoconjugates affords a versatile means to build biochemical
signals. These oligosaccharides have an exceptional talent in this respect. They surpass …

The sugar code: functional lectinomics

HJ Gabius, S André, H Kaltner, HC Siebert - Biochimica et Biophysica Acta …, 2002 - Elsevier
Analysis of the genome and proteome assumes the focus of attention in efforts to relate
biochemical coding with cell functionality. Among other chores in energy metabolism, the …

Chemical biology of the sugar code

HJ Gabius, HC Siebert, S André… - …, 2004 - Wiley Online Library
A high‐density coding system is essential to allow cells to communicate efficiently and
swiftly through complex surface interactions. All the structural requirements for forming a …

An introduction to the sugar code

HJ Gabius, J Roth - Histochemistry and cell biology, 2017 - Springer
Carbohydrates have physiological importance far beyond their roles as source of energy
(glycolysis) and activated hydrogen for synthesis (pentosephosphate pathway) or as …

What is the sugar code?

HJ Gabius, M Cudic, T Diercks, H Kaltner… - …, 2022 - Wiley Online Library
A code is defined by the nature of the symbols, which are used to generate information‐
storing combinations (eg oligo‐and polymers). Like nucleic acids and proteins, oligo‐and …