Obesity is associated with ovulatory disorders, decreased rates of conception, infertility,
early pregnancy loss and congenital abnormalities. Poor oocyte quality and reduced IVF …

The negative impact of obesity on reproductive success is well documented but the stages at
which development of the conceptus is compromised and the mechanisms responsible for …

Insulin resistance is a key defect associated with obesity, type 2 diabetes and other
metabolic diseases. While a number of factors have been suggested to cause defects in …

Over-nutrition in females causes altered fetal growth during pregnancy and permanently
programs the metabolism of offspring; however, the temporal and mechanistic origins of …

Optimal energy production is required for oocyte and embryo development, and
mitochondrial abnormalities have devastating reproductive consequences. Improvement of …

The development of oocytes and early embryos is dependent on mitochondrial ATP
production. This reliance on mitochondrial activity, together with the exclusively maternal …

Mounting evidence suggests a role for mitochondrial dysfunction in the pathogenesis of
many diseases, including type 2 diabetes, aging, and ovarian failure. Because of the central …

Maternal obesity can cause reduced oocyte quality and subfertility. Mitochondrial
dysfunction plays a central role here, and most often inbred mouse models are used to study …

Mitochondria play vital roles in oocyte functions and they are critical indicators of oocyte
quality which is important for fertilization and development into viable offspring. Quality …

The proportion of pregnant women who are obese at conception continues to rise.
Compelling evidence suggests the intrauterine environment is an important determinant of …