Mitochondria are the most prominent organelle in the oocyte. Somatic cells maintain a
healthy population of mitochondria by degrading damaged mitochondria via mitophagy, a …

Oocyte mitochondria are unique organelles that establish a founder population in primordial
germ cells (PGCs). As the oocyte matures in the postnatal mammalian ovary during …

Overweight or obese women seeking pregnancy is becoming increasingly common. Human
maternal obesity gives rise to detrimental effects during reproduction. Emerging evidence …

The adverse effects of maternal diabetes on embryo development and pregnancy outcomes
have recently been shown to occur as early as the one-cell zygote stage. The hypothesis of …

BACKGROUND Mitochondria are multitasking organelles involved in ATP synthesis,
reactive oxygen species (ROS) production, calcium signalling and apoptosis; and …

Oocyte mitochondrial dysfunction has been proposed as a cause of high levels of
developmental retardation and arrest that occur in human preimplantation embryos …

Mitochondria are well known as 'the powerhouses of the cell'. Indeed, their major role is
cellular energy production driven by both mitochondrial and nuclear DNA. Such a feature …

Mitochondria play an essential role in generating energy for embryo development and
maintaining embryo metabolism through key cellular functions including ion homeostasis …

In addition to their role in generating energy (ATP), other possible regulatory functions for
mitochondria in the mature oocyte, preimplantation stage embryo and differentiating …

The decline of oocyte quality has profound impacts on fertilization, implantation, embryonic
development, and the genetic quality of future generations. One factor that is often ignored …