Background Macrophage infiltration is crucial for colorectal cancer (CRC) immunotherapy.
Detailed classification of macrophage subsets will facilitate the selection of patients suitable …

Background The Immunoscore method, based on the distribution of the quantification of
cytotoxic and memory T cells, provides an indicator of tumor recurrence for colon cancer …

Purpose This study attempted to reveal the prognostic impact of microsatellite instability-high
(MSI-H) colon cancer with tumor-infiltrating immune cells (TIICs) and immune checkpoint …

Immunotherapy has achieved efficacy for advanced colorectal cancer (CRC) patients with a
mismatch-repair-deficient (dMMR) subtype. However, little immunotherapy efficacy was …

Background The tumor microenvironment plays an essential role in the therapeutic
response to immunotherapy. It is necessary to identify immune cell infiltration (ICI) subtypes …

Background Biomarkers based on immune context may guide prognosis prediction. T-cell
inactivation, exclusion, or dysfunction could cause unfavorable tumor microenvironments …

Background Current stratification systems for tumor prognostic prediction and
immunotherapeutic efficacy evaluation are less satisfying in colorectal cancer (CRC). As …

Background: The MSI/MSS status does not fully explain cancer immunotherapy response in
colorectal cancer. Thus, we developed a colorectal cancer-specific method that predicts …

Immune composition is commonly heterogeneous and varies among colorectal cancer
(CRC) patients. A comprehensive immune classification may act as important characteristics …

Abstract Tumor-associated macrophages (TAMs), one of the major immune cell types in
colorectal cancer (CRC) tumor microenvironment (TME), play indispensable roles in …