Topography of the extracellular environment is now recognized as a major biophysical
regulator of cell behavior and function. The study of the influence of patterned substrates on …

The human corneal basement membrane has a rich felt-like surface topography with feature
dimensions between 20 nm and 200 nm. On the basis of these findings, we designed …

In the presence of anisotropic biochemical or topographical patterns, cells tend to align in
the direction of these cues—a widely reported phenomenon known as" contact guidance." …

Topographic patterns are known to affect cellular processes such as adhesion, migration
and differentiation. However, the optimal way to deliver topographic signals to provide cells …

The mesenchymal tissue component of the teleost pectoral fin bud has been explanted onto
microfabricated quartz discs containing patterns of regular grooves of dimensions similar to …

Influencing cell behavior from proliferation to differentiation using substrate or implant
topography is an attractive strategy for regenerative medicine applications. Substrate …

Cell adhesion, orientation and migration are influenced by surface topographies in the
micrometer and nanometer range. In this work, we demonstrate the stimulation by …

The effects of the topography, adhesiveness and chemistry of surfaces in modulating the
behaviour of cells in vivo and in vitro have been extensively researched. However, few …

In order for cells to react to topography, they must be able to sense shape. When
considering nano-topography, these shapes are much smaller than the cell, but still strong …

High-throughput screening (HTS) methods based on topography gradients or arrays have
been extensively used to investigate cell–material interactions. However, it is a huge …