Chronic myeloid leukemia (CML) is a hematological disorder caused by the oncogenic BCR-
ABL fusion protein in more than 90% of patients. Despite the striking improvements in the …

Myeloid hematological malignancies are clonal bone marrow neoplasms, comprising of
acute myeloid leukemia (AML), the myelodysplastic syndromes (MDS), chronic …

The essential role of epigenetic modification in the pathogenesis of a series of cancers have
gradually been recognized. Histone deacetylase (HDACs), as well-known epigenetic …

Histone deacetylases (HDACs) are a key component of the epigenetic machinery regulating
gene expression, and behave as oncogenes in several cancer types, spurring the …

Histone deacetylase inhibitors (HDACi) represent a novel class of targeted drugs which alter
the acetylation status of several cellular proteins. These agents, modulating both chromatin …

Histone deacetylase inhibitors (HDIs) promote or enhance several different anticancer
mechanisms and therefore are in evidence as potential antileukemia agents. Studies on …

Histone deacetylases (HDACs) play a central role in the epigenetic regulation of gene
expression. Aberrant activity of HDACs has been found in several human cancers leading to …

Histone deacetylase inhibitors (HDACi) can induce hyperacetylation of both histone and non-
histone target resulting in epigenetic reprogramming and altered activity, stability and …

Introduction: Epigenetic changes and mutations in epigenetic modifiers characterize and
likely drive many cases of acute myeloid leukemia and myelodysplastic syndrome …

Normal hematopoiesis requires the accurate orchestration of lineage-specific patterns of
gene expression at each stage of development, and epigenetic regulators play a vital role …