Background To shed light on the earliest events in oncogenesis, there is growing interest in
understanding the mutational landscapes of normal tissues across ages. In the last decade …

Somatic mutations accumulate in multiple organs and tissues during aging and are a known
cause of cancer. Here we tested whether mutations accumulate during replicative …

Editorial summary Signatures of mutagenesis provide a powerful tool for dissecting the role
of somatic mutations in both normal and pathological processes. Significantly, cancer …

Cancer is a disease of aging fueled by the accumulation of somatic mutations. While
mutations in tumors are well characterized, little is known about the early mutational …

Aging is associated with an increased risk of cancer, possibly in part because of an age-
related increase in mutations in normal tissues. Due to their extremely low abundance …

Normal tissues progressively acquire mutations. Some mutations are positively selected,
driving clonal expansions that may colonize the majority of a tissue by old age. In several …

Background The lifelong accumulation of somatic mutations underlies age-related
phenotypes and cancer. Mutagenic forces are thought to shape the genome of aging cells in …

The genome of multicellular organisms carries the hereditary information necessary for the
development of all organs and tissues and to maintain function in adulthood. To ensure the …

Background Somatic mutations in healthy tissues contribute to aging, neurodegeneration,
and cancer initiation, yet they remain largely uncharacterized. Results To gain a better …

From conception to death, human cells accumulate somatic mutations in their genomes.
These mutations can contribute to the development of cancer and non-malignant diseases …