The biologically relevant coordination chemistry of iron and nitric oxide: electronic structure and reactivity

N Lehnert, E Kim, HT Dong, JB Harland… - Chemical …, 2021 - ACS Publications
Nitric oxide (NO) is an important signaling molecule that is involved in a wide range of
physiological and pathological events in biology. Metal coordination chemistry, especially …

Heme-nitrosyls: electronic structure implications for function in biology

AP Hunt, N Lehnert - Accounts of Chemical Research, 2015 - ACS Publications
Conspectus The question of why mammalian systems use nitric oxide (NO), a potentially
hazardous and toxic diatomic, as a signaling molecule to mediate important functions such …

Dinitrosyl iron complexes (DNICs): from biomimetic synthesis and spectroscopic characterization toward unveiling the biological and catalytic roles of DNICs

ML Tsai, CC Tsou, WF Liaw - Accounts of chemical research, 2015 - ACS Publications
Conspectus Dinitrosyl iron complexes (DNICs) have been recognized as storage and
transport agents of nitric oxide capable of selectively modifying crucial biological targets via …

Electronic structure of heme-nitrosyls and its significance for nitric oxide reactivity, sensing, transport, and toxicity in biological systems

LE Goodrich, F Paulat, VKK Praneeth… - Inorganic …, 2010 - ACS Publications
This review summarizes recent developments in the investigation of the electronic
structures, spectroscopic properties, and reactivities of ferrous and ferric heme-nitrosyls and …

Interplay between iron complexes, nitric oxide and sulfur ligands: Structure,(photo) reactivity and biological importance

K Szaciłowski, A Chmura, Z Stasicka - Coordination Chemistry Reviews, 2005 - Elsevier
Nitric oxide is one of the most important signalling and regulatory molecule in all animal and
plant organisms. Various iron complexes are involved in numerous steps of nitric oxide …

Reaction mechanisms relevant to the formation of iron and ruthenium nitric oxide complexes

PC Ford, LE Laverman - Coordination chemistry reviews, 2005 - Elsevier
Presented here is a review of recent mechanistic work related to the formation of iron and
ruthenium nitrosyl complexes. Given the importance of NO as a biological molecule and that …

Bioinspired Heme, Heme/Nonheme Diiron, Heme/Copper, and Inorganic NOx Chemistry: •NO(g) Oxidation, Peroxynitrite−Metal Chemistry, and •NO(g) Reductive …

MP Schopfer, J Wang, KD Karlin - Inorganic chemistry, 2010 - ACS Publications
The focus of this Forum Article highlights work from our own laboratories and those of others
in the area of biochemical and biologically inspired inorganic chemistry dealing with nitric …

Interaction of nitric oxide with tetrathiolato iron (II) complexes: relevance to the reaction pathways of iron nitrosyls in sulfur-rich biological coordination environments

TC Harrop, D Song, SJ Lippard - Journal of the American …, 2006 - ACS Publications
The mechanism of formation of dinitrosyl iron complexes (DNICs) coordinated by cysteine
residues at iron− sulfur protein sites has received little attention in the chemical literature. As …

Comparison of the reactivity of nitric oxide and nitroxyl with heme proteins: a chemical discussion of the differential biological effects of these redox related products of …

KM Miranda, RW Nims, DD Thomas, MG Espey… - Journal of inorganic …, 2003 - Elsevier
Investigations on the biological effects of nitric oxide (NO) derived from nitric oxide synthase
(NOS) have led to an explosion in biomedical research over the last decade. The chemistry …

The biology and chemistry of high-valent iron–oxo and iron–nitrido complexes

J Hohenberger, K Ray, K Meyer - Nature communications, 2012 - nature.com
Selective functionalization of unactivated C–H bonds and ammonia production are
extremely important industrial processes. A range of metalloenyzmes achieve these …