Spinally projecting serotonergic neurons play a key role in controlling pain sensitivity and
can either increase or decrease nociception depending on physiological context. It is …

Pain thresholds are, in part, set as a function of emotional and internal states by descending
modulation of nociceptive transmission in the spinal cord. Neurons of the rostral …

Background: The rostral ventromedial medulla (RVM) is a key brainstem structure that
conveys powerful descending influence of the central pain-modulating system on spinal …

Pontospinal noradrenergic neurons are thought to form part of a descending endogenous
analgesic system that exerts inhibitory influences on spinal nociception. Using optogenetic …

Serotonergic neurons in the rostral ventral medulla (RVM) contribute to bidirectional control
of pain through modulation of spinal and trigeminal nociceptive networks. Deficits in this …

The parabrachial nucleus (PBN) is one of the major targets of spinal projection neurons and
plays important roles in pain. However, the architecture of the spinoparabrachial pathway …

The thalamocortical (TC) circuit is closely associated with pain processing. The
hyperpolarization-activated cyclic nucleotide-gated (HCN) 2 channel is predominantly …

The rostral ventromedial medulla (RVM) exerts bidirectional descending modulation of pain
attributable to the activity of electrophysiologically identified pronociceptive ON and …

The supraspinal descending pain modulatory system (DPMS) shapes pain perception via
monoaminergic modulation of sensory information in the spinal cord. However, the role and …

Understanding how neuronal circuits control nociceptive processing will advance the search
for novel analgesics. We use functional imaging to demonstrate that lateral hypothalamic …