Polymer nanomedicines

J Kopeček, J Yang - Advanced drug delivery reviews, 2020 - Elsevier
Polymer nanomedicines (macromolecular therapeutics, polymer-drug conjugates, drug-free
macromolecular therapeutics) are a group of biologically active compounds that are …

Polymer–drug conjugates: Origins, progress to date and future directions

J Kopeček - Advanced drug delivery reviews, 2013 - Elsevier
This overview focuses on bioconjugates of water-soluble polymers with low molecular
weight drugs and proteins. After a short discussion of the origins of the field, the state-of-the …

Macromolecular therapeutics

J Yang, J Kopeček - Journal of Controlled Release, 2014 - Elsevier
This review covers water-soluble polymer–drug conjugates and macromolecules that
possess biological activity without attached low molecular weight drugs. The main design …

Polymer conjugates: nanosized medicines for treating cancer

MJ Vicent, R Duncan - Trends in biotechnology, 2006 - cell.com
Interdisciplinary research at the interface of polymer chemistry and the biomedical sciences
has produced the first polymer-based nanomedicines for the diagnosis and treatment of …

Polymer–drug conjugates as nano-sized medicines

F Canal, J Sanchis, MJ Vicent - Current opinion in biotechnology, 2011 - Elsevier
Polymer Therapeutics have enormously evolved in the past decades. Several polymeric
drugs as well as polymer–protein conjugates have been in the market since the 90s, but …

Design of smart HPMA copolymer-based nanomedicines

J Yang, J Kopeček - Journal of Controlled Release, 2016 - Elsevier
The state-of-the art in water-soluble macromolecular therapeutics has been reviewed. First
the design principles for polymer-drug conjugates are discussed followed by two recent …

Polymer–drug conjugate therapeutics: advances, insights and prospects

I Ekladious, YL Colson, MW Grinstaff - Nature reviews Drug discovery, 2019 - nature.com
Polymer–drug conjugates have long been a mainstay of the drug delivery field, with several
conjugates successfully translated into clinical practice. The conjugation of therapeutic …

Polymer-drug conjugates as nanomedicine: a review

ML Girase, PG Patil, PP Ige - International Journal of Polymeric …, 2020 - Taylor & Francis
The majority of anti-cancer drugs show poor water solubility and produce adverse effects in
healthy tissue. The combination of polymer technology and targeted drug delivery system …

Anticancer polymeric nanomedicines

R Tong, J Cheng - Journal of Macromolecular Science, Part C …, 2007 - Taylor & Francis
Polymers play important roles in the design of delivery nanocarriers for cancer therapies.
Polymeric nanocarriers with anticancer drugs conjugated or encapsulated, also known as …

Targeted polymer-drug conjugates: current progress and future perspective

H Xu, H Ma, P Yang, X Zhang, X Wu, W Yin… - Colloids and Surfaces B …, 2015 - Elsevier
The combination of polymer technology and targeted drug delivery may pave the way for
more effective yet safer therapeutic options for cancer therapy. Polymer-drug conjugates …