Both humans and animals exhibit marked individual differences in cocaine responsiveness.
By using the median split of cocaine-induced locomotor activity, we have classified outbred …

Abstract Outbred male Sprague–Dawley rats can be classified as either low or high cocaine
responders (LCRs or HCRs, respectively) based on their locomotor response to acute …

Individual differences are a hallmark of drug addiction. Here, we describe a rat model based
on differential initial responsiveness to low dose cocaine. Despite similar brain cocaine …

Adult outbred Sprague–Dawley rats can be classified as either low or high cocaine
responders (LCRs or HCRs, respectively). Importantly, LCRs and HCRs are distinguished …

Previously we found that outbred male Sprague–Dawley rats can be classified as either low
or high cocaine responders (LCRs or HCRs, respectively), based on their open-field …

Behavioral sensitization to cocaine reflects neuroadaptive changes that intensify drug
effects. However, repeated cocaine administration does not induce behavioral sensitization …

Behavioral responses of rodents to cocaine are characterized by marked individual
variability. Here, outbred male Sprague-Dawley rats were profiled based on concomitant …

Sex and individual differences are important considerations when studying cocaine
responsiveness. We have previously shown that male Sprague–Dawley (S–D) rats can be …

Rationale: Although the rewarding effects of cocaine are generally attributed to its ability to
increase dopamine (DA) transmission, cocaine demonstrates approximately equal affinity for …

Tolerance to the neurochemical and psychoactive effects of cocaine after repeated use is a
hallmark of cocaine addiction in humans. However, comprehensive studies on tolerance to …