Background Continuous intravenous (IV) morphine is commonly used in ventilated
neonates. Oral route is theoretically feasible but data on oral morphine in ventilated …

ContextNewborns admitted to neonatal intensive care units (NICUs) undergo a variety of
painful procedures and stressful events. Because the effect of continuous morphine infusion …

Background Opioid analgesia is commonly used during neonatal intensive care. We
undertook the Neurologic Outcomes and Pre-emptive Analgesia in Neonates (NEOPAIN) …

RESULTS• There was no difference in the primary composite outcome of severe IVH, PVL,
and/or neonatal death between morphine and placebo groups (27%[115/419] versus …

Objective To determine the safety of morphine for procedural pain management in
nonintubated infants in the neonatal intensive care unit. Methods Retrospective cohort study …

Eighty-three infants received iv morphine following surgery as a continuous infusion to a
targeted morphine concentration of 20 ng ml− 1 (n= 56) or as intermittent bolus doses as …

OBJECTIVE: To test the hypothesis that use of morphine for sedation of ventilated premature
neonates has not changed despite evidence-based recommendations. STUDY DESIGN …

Background: Pain control in neonates is an important clinical concern with potential long-
term adverse neurodevelopmental effects. Intravenous morphine is routinely administered …

A randomized double-blind clinical trial compared the efficacy of 10μg/kg/h morphine
continuous intravenous infusion (CM) with that of 30μg/kg morphine (IM) every 3h after …

Objective: To determine the effect of morphine on duration of mechanical ventilation, apnoea
and hypotension among full-term neonates who underwent thoracic or abdominal surgery in …